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rdf:type |
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lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0017337,
umls-concept:C0024858,
umls-concept:C0043038,
umls-concept:C0043210,
umls-concept:C0043346,
umls-concept:C0079170,
umls-concept:C0332281,
umls-concept:C0376315,
umls-concept:C0596244,
umls-concept:C0599755,
umls-concept:C1882417
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pubmed:issue |
1
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pubmed:dateCreated |
2007-1-8
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pubmed:abstractText |
The genes mutated in the cancer-prone syndrome, xeroderma pigmentosum (XP genes), have been well studied both biochemically and mechanistically. These genes are important components of the DNA nucleotide excision repair (NER) pathway, which protects against environmentally-induced cancers. XP genes are also downstream of the hereditary breast cancer syndrome gene, BRCA1, suggesting that XP genes may be important to hereditary forms of breast cancer as well. Although mutated XP genes are rare, polymorphic forms with potential functional deficiencies are common, and could pose a significant cancer risk in the general population.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0167-6806
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-71
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:16823510-Breast Neoplasms,
pubmed-meshheading:16823510-Cohort Studies,
pubmed-meshheading:16823510-DNA Repair,
pubmed-meshheading:16823510-Female,
pubmed-meshheading:16823510-Gene Frequency,
pubmed-meshheading:16823510-Genetic Predisposition to Disease,
pubmed-meshheading:16823510-Genotype,
pubmed-meshheading:16823510-Humans,
pubmed-meshheading:16823510-Maryland,
pubmed-meshheading:16823510-Middle Aged,
pubmed-meshheading:16823510-Multivariate Analysis,
pubmed-meshheading:16823510-Polymorphism, Single Nucleotide,
pubmed-meshheading:16823510-Risk Factors,
pubmed-meshheading:16823510-Xeroderma Pigmentosum
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pubmed:year |
2007
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pubmed:articleTitle |
Breast cancer risk is not associated with polymorphic forms of xeroderma pigmentosum genes in a cohort of women from Washington County, Maryland.
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pubmed:affiliation |
Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road, NW, TRB Room E212, Washington, DC 20057, USA. tjorge01@georgetown.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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