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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-7-6
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pubmed:abstractText |
Crouzon syndrome is caused by mutations in fibroblast growth factor receptor 2 (FGFR2) leading to constitutive activation of receptors in the absence of ligand binding. The syndrome is characterized by premature fusion of the cranial sutures that leads to abnormal cranium shape, restricted brain growth, and increased intracranial pressure. Surgical remodeling of the cranial vault is currently used to treat affected infants. The purpose of this study was to develop a pharmacological strategy using tyrosine kinase inhibition as a novel treatment for craniosynostotic syndromes caused by constitutive FGFR activation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-10394936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-10572038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-10638483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-10647936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-11121055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-11151714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-11173845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-11743369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-14715624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-14719210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-15060342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-15116089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-15316116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-15564323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-16313397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-1633640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-1923223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-393319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-7655462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-7719345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-7773297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-7987400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-8644708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-8841188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-9020696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-9207932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-9300656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-9310332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-9700203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16823318-9774334
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4040
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
210-5; discussion 210-5
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:16823318-Animals,
pubmed-meshheading:16823318-Cranial Sutures,
pubmed-meshheading:16823318-Craniofacial Dysostosis,
pubmed-meshheading:16823318-Cysteine,
pubmed-meshheading:16823318-Disease Models, Animal,
pubmed-meshheading:16823318-Mice,
pubmed-meshheading:16823318-Mice, Mutant Strains,
pubmed-meshheading:16823318-Mutation,
pubmed-meshheading:16823318-Pyrimidines,
pubmed-meshheading:16823318-Receptor, Fibroblast Growth Factor, Type 2,
pubmed-meshheading:16823318-Receptors, Fibroblast Growth Factor,
pubmed-meshheading:16823318-Tissue Culture Techniques,
pubmed-meshheading:16823318-Tomography, X-Ray Computed,
pubmed-meshheading:16823318-Tyrosine
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pubmed:year |
2006
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pubmed:articleTitle |
A model for the pharmacological treatment of crouzon syndrome.
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pubmed:affiliation |
Division of Plastic Surgery and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. cperlyn@molecool.wustl.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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