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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1991-12-6
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pubmed:abstractText |
The effect of Xiao-chai-hu-tang (TJ-9) on hepatocarcinogenesis induced by N-nitrosomorpholine (NNM) was investigated in male Sprague-Dawley rats. Rats were given normal chow pellets containing 0.5% or 1.0% TJ-9 until the end of the experiment, and drinking water containing NNM for 8 weeks. Pre-neoplastic and neoplastic lesions staining for gamma-glutamyl transpeptidase (GGT) or the placental type of glutathione-S-transferase (GST-P) were examined histochemically. In Week 15, quantitative histological analysis showed that prolonged treatment with 0.5% TJ-9 significantly reduced the number and volume of GGT-positive and GST-P-positive hepatic lesions. Treatment with 1.0% TJ-9 inhibited the development of GGT-positive and GST-P-positive lesions, but was less effective than 0.5% TJ-9. Administration of 0.5% TJ-9 also caused a significant increase in the proportion of helper T lymphocytes and a significant decrease in the labeling index of pre-neoplastic lesions. These findings indicate that TJ-9 inhibits the development of hepatic foci.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0910-5050
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
987-92
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1682293-Animals,
pubmed-meshheading:1682293-Antineoplastic Agents,
pubmed-meshheading:1682293-Body Weight,
pubmed-meshheading:1682293-Carcinogens,
pubmed-meshheading:1682293-Carcinoma, Hepatocellular,
pubmed-meshheading:1682293-Drugs, Chinese Herbal,
pubmed-meshheading:1682293-Glutathione Transferase,
pubmed-meshheading:1682293-Liver,
pubmed-meshheading:1682293-Liver Neoplasms, Experimental,
pubmed-meshheading:1682293-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:1682293-Male,
pubmed-meshheading:1682293-Nitrosamines,
pubmed-meshheading:1682293-Organ Size,
pubmed-meshheading:1682293-Rats,
pubmed-meshheading:1682293-Rats, Inbred Strains,
pubmed-meshheading:1682293-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:1682293-gamma-Glutamyltransferase
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pubmed:year |
1991
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pubmed:articleTitle |
Inhibition by xiao-chai-hu-tang (TJ-9) of development of hepatic foci induced by N-nitrosomorpholine in Sprague-Dawley rats.
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pubmed:affiliation |
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka.
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pubmed:publicationType |
Journal Article
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