Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-7-6
pubmed:abstractText
Outcome for children with childhood acute lymphoblastic leukemia (ALL) who relapse is poor. To gain insight into the mechanisms of relapse, we analyzed gene-expression profiles in 35 matched diagnosis/relapse pairs as well as 60 uniformly treated children at relapse using the Affymetrix platform. Matched-pair analyses revealed significant differences in the expression of genes involved in cell-cycle regulation, DNA repair, and apoptosis between diagnostic and early-relapse samples. Many of these pathways have been implicated in tumorigenesis previously and are attractive targets for intervention strategies. In contrast, no common pattern of changes was observed among late-relapse pairs. Early-relapse samples were more likely to be similar to their respective diagnostic sample while we noted greater divergence in gene-expression patterns among late-relapse pairs. Comparison of expression profiles of early- versus late-relapse samples indicated that early-relapse clones were characterized by overexpression of biologic pathways associated with cell-cycle regulation. These results suggest that early-relapse results from the emergence of a related clone, characterized by the up-regulation of genes mediating cell proliferation. In contrast, late relapse appears to be mediated by diverse pathways.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-10090949, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-10216470, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-10759711, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-10995007, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-11309499, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-11380395, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-11557892, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-12368249, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-12509766, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-12925520, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-14673046, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-14749704, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-14749762, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-15155462, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-15208674, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-15242522, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-15328172, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-15591335, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-15682439, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-15816528, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-15897551, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-15982346, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-16281934, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-16351633, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-7812005, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-8748093, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-8751464, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-9028333, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-9207134, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-9529033, http://linkedlifedata.com/resource/pubmed/commentcorrection/16822902-9705843
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
711-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Biologic pathways associated with relapse in childhood acute lymphoblastic leukemia: a Children's Oncology Group study.
pubmed:affiliation
New York University (NYU) Cancer Institute and Division of Pediatric Hematology/Oncology, NY 10016, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural