rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-7-6
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pubmed:abstractText |
Outcome for children with childhood acute lymphoblastic leukemia (ALL) who relapse is poor. To gain insight into the mechanisms of relapse, we analyzed gene-expression profiles in 35 matched diagnosis/relapse pairs as well as 60 uniformly treated children at relapse using the Affymetrix platform. Matched-pair analyses revealed significant differences in the expression of genes involved in cell-cycle regulation, DNA repair, and apoptosis between diagnostic and early-relapse samples. Many of these pathways have been implicated in tumorigenesis previously and are attractive targets for intervention strategies. In contrast, no common pattern of changes was observed among late-relapse pairs. Early-relapse samples were more likely to be similar to their respective diagnostic sample while we noted greater divergence in gene-expression patterns among late-relapse pairs. Comparison of expression profiles of early- versus late-relapse samples indicated that early-relapse clones were characterized by overexpression of biologic pathways associated with cell-cycle regulation. These results suggest that early-relapse results from the emergence of a related clone, characterized by the up-regulation of genes mediating cell proliferation. In contrast, late relapse appears to be mediated by diverse pathways.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-4971
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pubmed:author |
pubmed-author:Belitskaya-LevyIlanaI,
pubmed-author:BhojwaniDeepaD,
pubmed-author:BorowitzMichael JMJ,
pubmed-author:CarrollWilliam LWL,
pubmed-author:DavidsonGeorgeG,
pubmed-author:HungerStephen PSP,
pubmed-author:KangHuiningH,
pubmed-author:LeeHokyungH,
pubmed-author:MinDong-JoonDJ,
pubmed-author:MoskowitzNaomi PNP,
pubmed-author:PotterJeffrey WJW,
pubmed-author:RaetzElizabeth AEA,
pubmed-author:WillmanCheryl LCL
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
711-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16822902-Apoptosis,
pubmed-meshheading:16822902-Cell Cycle,
pubmed-meshheading:16822902-Cell Proliferation,
pubmed-meshheading:16822902-Child,
pubmed-meshheading:16822902-Clone Cells,
pubmed-meshheading:16822902-DNA Repair,
pubmed-meshheading:16822902-Gene Expression Profiling,
pubmed-meshheading:16822902-Humans,
pubmed-meshheading:16822902-Matched-Pair Analysis,
pubmed-meshheading:16822902-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:16822902-Recurrence,
pubmed-meshheading:16822902-Time Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Biologic pathways associated with relapse in childhood acute lymphoblastic leukemia: a Children's Oncology Group study.
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pubmed:affiliation |
New York University (NYU) Cancer Institute and Division of Pediatric Hematology/Oncology, NY 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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