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pubmed-article:16822169pubmed:abstractTextMeta-analyses were conducted to determine the magnitude of relationships between polymorphisms in 2 genes, ALDH2 and ADH1B, with alcohol dependence in Asians. For each gene, possession of 1 variant *2 allele was protective against alcohol dependence, and possession of a 2nd *2 allele did not offer significant additional protection. The protective effects of these 2 gene polymorphisms were independent. Diagnostic criteria, recruitment strategy, and Japanese ethnicity moderated the effect of ALDH2*2. Recruitment strategy and gender moderated the effect of ADH1B*2. These findings highlight the importance of methodological issues and potential gene-gene and gene-environment interactions that must be considered when examining relationships between genetic polymorphisms and phenotypes.lld:pubmed
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pubmed-article:16822169pubmed:copyrightInfoCopyright (c) 2006 APA, all rights reserved.lld:pubmed
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pubmed-article:16822169pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:16822169pubmed:articleTitleMeta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians.lld:pubmed
pubmed-article:16822169pubmed:affiliationDepartment of Psychology, University of Southern California, Los Angeles 90089-1061, and the Veterans Medical Research Foundation, San Diego, CA, USA. luczak@usc.edulld:pubmed
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