Linked Life Data

16822169

Source:http://linkedlifedata.com/resource/pubmed/id/16822169

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-7-6
pubmed:abstractText
Meta-analyses were conducted to determine the magnitude of relationships between polymorphisms in 2 genes, ALDH2 and ADH1B, with alcohol dependence in Asians. For each gene, possession of 1 variant *2 allele was protective against alcohol dependence, and possession of a 2nd *2 allele did not offer significant additional protection. The protective effects of these 2 gene polymorphisms were independent. Diagnostic criteria, recruitment strategy, and Japanese ethnicity moderated the effect of ALDH2*2. Recruitment strategy and gender moderated the effect of ADH1B*2. These findings highlight the importance of methodological issues and potential gene-gene and gene-environment interactions that must be considered when examining relationships between genetic polymorphisms and phenotypes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0033-2909
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2006 APA, all rights reserved.
pubmed:issnType
Print
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
607-21
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians.
pubmed:affiliation
Department of Psychology, University of Southern California, Los Angeles 90089-1061, and the Veterans Medical Research Foundation, San Diego, CA, USA. luczak@usc.edu
pubmed:publicationType
Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural