Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1991-12-6
|
| pubmed:abstractText |
Somatostatin-28 (S-28), originating in gastrointestinal cells, is secreted into the circulatory system and rises in human plasma after ingestion of a mixed meal. Pancreatic beta-cells contain specific, high-affinity receptors for S-28, and it is plausible that this peptide is a physiological modulator of insulin secretion. To evaluate the effects of physiological concentrations of S-28 on glucose-mediated insulin secretion, we used the perfused in situ rat pancreas under two conditions: 1) "square-wave" glucose infusion from 2.8 to 11.1 mM and 2) ramping of glucose at 0.28 mM/min throughout 45 min. S-28 concentrations of 16, 32, and 80 pM were separately coinfused for 40 min in the first condition and at 16 pM in the second condition. During square-wave glucose infusion, biphasic insulin secretion was elicited with marked attenuation of both phases during coinfusion with the two higher concentrations of S-28. At 16 pM S-28, which approximates postprandial At 16 pM S-28, which approximates postprandial concentrations, only first-phase secretion was suppressed. During ramping of glucose, insulin was released gradually and, in the presence of 16 pM S-28, was shifted to the right, indicating an increase in threshold glucose levels for insulin secretion. We concluded that S-28, at levels achieved postprandially, modulates the release of insulin by altering the threshold of sensitivity to glucose.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0012-1797
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1163-9
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1682197-Adult,
pubmed-meshheading:1682197-Animals,
pubmed-meshheading:1682197-Dose-Response Relationship, Drug,
pubmed-meshheading:1682197-Fasting,
pubmed-meshheading:1682197-Humans,
pubmed-meshheading:1682197-Insulin,
pubmed-meshheading:1682197-Islets of Langerhans,
pubmed-meshheading:1682197-Kinetics,
pubmed-meshheading:1682197-Male,
pubmed-meshheading:1682197-Middle Aged,
pubmed-meshheading:1682197-Perfusion,
pubmed-meshheading:1682197-Protein Precursors,
pubmed-meshheading:1682197-Rats,
pubmed-meshheading:1682197-Rats, Inbred Strains,
pubmed-meshheading:1682197-Reference Values,
pubmed-meshheading:1682197-Somatostatin,
pubmed-meshheading:1682197-Somatostatin-28,
pubmed-meshheading:1682197-Time Factors
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Effect of somatostatin-28 on dynamics of insulin secretion in perfused rat pancreas.
|
| pubmed:affiliation |
Department of Medicine, University of Washington, Seattle 98195.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|