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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3B
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pubmed:dateCreated |
2006-7-6
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pubmed:abstractText |
Methylenetetrahydrofolate reductase (MTHFR) plays a role in DNA biosynthesis, methylation and repair in actively dividing cells by acting on folate metabolism. A common C677T polymorphism in the gene for MTHFR leads to an enzyme with decreased activity. MTHFR polymorphisms have been studied in various cancers but not in primary brain tumors. The purpose of this case-control study was to explore a possible association between MTHFR C677T polymorphism and primary brain tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2445-9
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pubmed:meshHeading |
pubmed-meshheading:16821630-Alleles,
pubmed-meshheading:16821630-Brain Neoplasms,
pubmed-meshheading:16821630-Case-Control Studies,
pubmed-meshheading:16821630-Female,
pubmed-meshheading:16821630-Genotype,
pubmed-meshheading:16821630-Glioma,
pubmed-meshheading:16821630-Humans,
pubmed-meshheading:16821630-Male,
pubmed-meshheading:16821630-Meningeal Neoplasms,
pubmed-meshheading:16821630-Meningioma,
pubmed-meshheading:16821630-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:16821630-Middle Aged,
pubmed-meshheading:16821630-Polymorphism, Genetic,
pubmed-meshheading:16821630-Prospective Studies
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pubmed:articleTitle |
C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and high-grade gliomas.
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pubmed:affiliation |
Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
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pubmed:publicationType |
Journal Article
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