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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-7-5
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pubmed:abstractText |
A new human malignant rhabdoid tumor (MRT) cell line (designated FRTK-1) was established from MRT of the kidney of an 18-month-old boy. The cell line is maintained for over 24 months with more than 100 passages. FRTK-1 cells in vitro showed 2 different growth patterns, adherent and non-adherent patterns. The FRTK-1 cells showed the same morphological and immunophenotypical characteristics as primary tumor cells of kidney. Cytogenetic and molecular analyses revealed a non-sense mutation in the hSNF5/INI1 gene and loss of expression of hSNF5/INI1 gene product protein. Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) were expressed in the FRTK-1 cells. Until now, there has been no report of MRT cell lines with expression of COX-2. Therefore, FRTK-1 cell line might be useful for investigating biological behavior and developing new molecular targeting antitumor drugs for MRT with expression of EGFR or COX-2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/Codon, Nonsense,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1021-335X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
265-71
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16820901-Adolescent,
pubmed-meshheading:16820901-Blotting, Western,
pubmed-meshheading:16820901-Cell Adhesion,
pubmed-meshheading:16820901-Cell Line, Tumor,
pubmed-meshheading:16820901-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:16820901-Codon, Nonsense,
pubmed-meshheading:16820901-Cyclooxygenase 2,
pubmed-meshheading:16820901-Cytogenetic Analysis,
pubmed-meshheading:16820901-DNA-Binding Proteins,
pubmed-meshheading:16820901-Humans,
pubmed-meshheading:16820901-Kidney Neoplasms,
pubmed-meshheading:16820901-Male,
pubmed-meshheading:16820901-RNA, Messenger,
pubmed-meshheading:16820901-Receptor, Epidermal Growth Factor,
pubmed-meshheading:16820901-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16820901-Rhabdoid Tumor,
pubmed-meshheading:16820901-Sequence Analysis, DNA,
pubmed-meshheading:16820901-Transcription Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Establishment and characterization of a new cell line, FRTK-1, derived from human malignant rhabdoid tumor of the kidney, with overexpression of epidermal growth factor receptor and cyclooxygenase-2.
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pubmed:affiliation |
First Department of Pathology, Fukushima Medical University School of Medicine, Fukushima-shi, Japan. paco@fmu.ac.jp
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pubmed:publicationType |
Journal Article
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