Source:http://linkedlifedata.com/resource/pubmed/id/16820785
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2006-8-10
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pubmed:abstractText |
Both residual renal and dialytic clearance confer to the total solute clearance in dialysis patients. Dialytic clearances of the middle molecule beta-microglobulin (beta(2)M) and the protein-bound solute p-cresol (pcr) are generally believed to be higher with peritoneal dialysis (PD) as compared to hemodialysis (HD). Supportive data, however, are lacking. We performed a single-center cross-sectional observational study including 70 unselected patients treated with either high-flux HD (n=20) or PD (n=50). Mid-day serum levels (PD) and time-averaged concentrations (HD) of the water-soluble solutes urea nitrogen, creatinine and phosphate, the middle molecule beta(2)M, and the protein-bound solute pcr were determined. Dialytic solute clearances (l/week/1.73 m(2)) were calculated from total dialysate collection during the mid-week session in HD and 24 h dialysate collection in PD. Renal clearances were calculated for each of the respective solutes from a timed urine collection. Total clearances were obtained by summation. HD delivered significantly higher clearances of all retention solutes studied. This superiority was especially pronounced for pcr (30.9+/-62.7 vs 4.4+/-2.3, HD vs PD, P<0.0001) and beta(2)M (28.6+/-6.6 vs 5.8+/-3.1, HD vs PD, P<0.0001). Renal clearances, conversely, were significantly higher in patients on PD. Serum levels of all solutes but pcr were significantly lower in HD than in PD. Both a higher residual renal function and a lower generation rate contribute to the lower pcr levels in PD. In conclusion, superior dialytic clearance of both water-soluble solutes, beta(2)M, and pcr is achieved by high-flux HD as compared to PD.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-cresol,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Cresols,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0085-2538
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
794-9
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pubmed:dateRevised |
2007-4-12
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pubmed:meshHeading |
pubmed-meshheading:16820785-Adult,
pubmed-meshheading:16820785-Aged,
pubmed-meshheading:16820785-Blood Urea Nitrogen,
pubmed-meshheading:16820785-Creatinine,
pubmed-meshheading:16820785-Cresols,
pubmed-meshheading:16820785-Cross-Sectional Studies,
pubmed-meshheading:16820785-Female,
pubmed-meshheading:16820785-Humans,
pubmed-meshheading:16820785-Kidney,
pubmed-meshheading:16820785-Kidney Diseases,
pubmed-meshheading:16820785-Male,
pubmed-meshheading:16820785-Middle Aged,
pubmed-meshheading:16820785-Peritoneal Dialysis,
pubmed-meshheading:16820785-Phosphates,
pubmed-meshheading:16820785-Renal Dialysis,
pubmed-meshheading:16820785-beta 2-Microglobulin
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pubmed:year |
2006
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pubmed:articleTitle |
Superior dialytic clearance of beta(2)-microglobulin and p-cresol by high-flux hemodialysis as compared to peritoneal dialysis.
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pubmed:affiliation |
Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium. pieter.evenepoel@uz.kuleuven.ac.be
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
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