Source:http://linkedlifedata.com/resource/pubmed/id/16820703
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2006-8-30
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pubmed:abstractText |
CD8+ CD25+-activated cytotoxic T cells and anti-thyroglobulin antibodies (TgAb) are independently involved in the severity of Hashimoto's disease (HD). Interferon gamma (IFN-gamma) activates cytotoxic T cells. To evaluate the hypothesis that the functional +874A/T polymorphism in the gene encoding IFN-gamma is associated with the severity of HD, we examined the frequencies of this polymorphism in 34 HD patients who developed hypothyroidism (severe HD); 22 untreated, euthyroid HD patients (mild HD); 49 patients with intractable Graves' disease (GD); 16 GD patients in remission; and 57 healthy volunteers. Frequency of the +874T allele, which is associated with high IFN-gamma production, was higher in patients with severe HD than in those with mild HD (odds ratio [OR], 3.5; 95% confidence interval [CI], 1.0-12.4; p = 0.047), but there was no difference in the frequency between GD patients. The difference in the frequency of +874T was observed in the subset of patients with HD negative for TgAb (OR, 8.4; 95% CI, 1.2-57.3; p = 0.029) but not in the subset of patients with HD positive for TgAb. Our data indicate that the +874A/T polymorphism in the IFN-gamma gene is associated with severity of HD.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins, Thyroid-Stimulating,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin,
http://linkedlifedata.com/resource/pubmed/chemical/Thyroxine,
http://linkedlifedata.com/resource/pubmed/chemical/Triiodothyronine,
http://linkedlifedata.com/resource/pubmed/chemical/anti-thyroglobulin,
http://linkedlifedata.com/resource/pubmed/chemical/thyrotropin-binding inhibitory...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0918-8959
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
473-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16820703-Autoantibodies,
pubmed-meshheading:16820703-DNA,
pubmed-meshheading:16820703-Electrophoresis, Agar Gel,
pubmed-meshheading:16820703-Genotype,
pubmed-meshheading:16820703-Graves Disease,
pubmed-meshheading:16820703-Hashimoto Disease,
pubmed-meshheading:16820703-Humans,
pubmed-meshheading:16820703-Immunoglobulins, Thyroid-Stimulating,
pubmed-meshheading:16820703-Interferon-gamma,
pubmed-meshheading:16820703-Middle Aged,
pubmed-meshheading:16820703-Polymerase Chain Reaction,
pubmed-meshheading:16820703-Polymorphism, Single Nucleotide,
pubmed-meshheading:16820703-Statistics, Nonparametric,
pubmed-meshheading:16820703-Thyrotropin,
pubmed-meshheading:16820703-Thyroxine,
pubmed-meshheading:16820703-Triiodothyronine
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pubmed:year |
2006
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pubmed:articleTitle |
Association between the severity of Hashimoto's disease and the functional +874A/T polymorphism in the interferon-gamma gene.
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pubmed:affiliation |
Department of Biomedical Informatics, Division of Health Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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