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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1 Suppl
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pubmed:dateCreated |
2006-7-5
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pubmed:abstractText |
Calcific aortic valve stenosis is a common disease in the elderly and is characterized by progressive calcification and fibrous thickening of the valve, but the cellular and molecular mechanisms are not fully understood. We hypothesized that human valve interstitial cells (ICs) are able to differentiate into osteoblast-like cells through the influence of defined mediators and that this process can be modulated pharmacologically.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/BMP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/BMP4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/BMP7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 4,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 7,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media,
http://linkedlifedata.com/resource/pubmed/chemical/Heptanoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/TGFB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta3,
http://linkedlifedata.com/resource/pubmed/chemical/atorvastatin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
I547-52
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16820635-Aged,
pubmed-meshheading:16820635-Alkaline Phosphatase,
pubmed-meshheading:16820635-Aortic Valve,
pubmed-meshheading:16820635-Aortic Valve Stenosis,
pubmed-meshheading:16820635-Bone Morphogenetic Protein 2,
pubmed-meshheading:16820635-Bone Morphogenetic Protein 4,
pubmed-meshheading:16820635-Bone Morphogenetic Protein 7,
pubmed-meshheading:16820635-Bone Morphogenetic Proteins,
pubmed-meshheading:16820635-Calcinosis,
pubmed-meshheading:16820635-Cell Differentiation,
pubmed-meshheading:16820635-Cells, Cultured,
pubmed-meshheading:16820635-Connective Tissue Cells,
pubmed-meshheading:16820635-Culture Media,
pubmed-meshheading:16820635-Fibrosis,
pubmed-meshheading:16820635-Heptanoic Acids,
pubmed-meshheading:16820635-Humans,
pubmed-meshheading:16820635-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:16820635-Middle Aged,
pubmed-meshheading:16820635-Osteoblasts,
pubmed-meshheading:16820635-Osteocalcin,
pubmed-meshheading:16820635-Pyrroles,
pubmed-meshheading:16820635-Transforming Growth Factor beta,
pubmed-meshheading:16820635-Transforming Growth Factor beta1,
pubmed-meshheading:16820635-Transforming Growth Factor beta3
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pubmed:year |
2006
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pubmed:articleTitle |
Role of human valve interstitial cells in valve calcification and their response to atorvastatin.
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pubmed:affiliation |
Heart Science Centre, Royal Brompton and Harefield National Health Service Trust, Harefield, Middlesex, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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