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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1 Suppl
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pubmed:dateCreated |
2006-7-5
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pubmed:abstractText |
Tumor necrosis factor-alpha (TNF) is increased in myocardial tissue after ischemia and reperfusion (I/R). TNF contributes to postischemic myocardial dysfunction and induces proinflammatory signaling, which may be mediated by the 55-kDa TNF receptor (TNFR1). In humans, there is a direct correlation between functional capacity, survival, and circulating TNF levels. Although decreasing the TNF level in animals was beneficial after myocardial ischemia, simply decreasing the bioavailability of TNF in humans with heart failure was not beneficial. This led to the important appreciation that TNF may have beneficial or deleterious effects in the heart, depending on which of its receptors is activated. Females have a lower incidence of heart failure and a higher heart failure survival than males. We hypothesized that TNFR1 signaling resistance occurs in the female myocardium during ischemia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Socs3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Suppressor of Cytokine Signaling...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor Decoy...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/recombinant human tumor necrosis...
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
I282-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16820587-Animals,
pubmed-meshheading:16820587-Enzyme Activation,
pubmed-meshheading:16820587-Female,
pubmed-meshheading:16820587-Heart,
pubmed-meshheading:16820587-Interleukin-1,
pubmed-meshheading:16820587-Interleukin-6,
pubmed-meshheading:16820587-Male,
pubmed-meshheading:16820587-Mice,
pubmed-meshheading:16820587-Mice, Inbred C57BL,
pubmed-meshheading:16820587-Mice, Knockout,
pubmed-meshheading:16820587-Myocardial Ischemia,
pubmed-meshheading:16820587-Myocardial Reperfusion Injury,
pubmed-meshheading:16820587-Myocardium,
pubmed-meshheading:16820587-Myocytes, Cardiac,
pubmed-meshheading:16820587-Phosphorylation,
pubmed-meshheading:16820587-Protein Processing, Post-Translational,
pubmed-meshheading:16820587-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:16820587-Receptors, Tumor Necrosis Factor, Type I,
pubmed-meshheading:16820587-Receptors, Tumor Necrosis Factor, Type II,
pubmed-meshheading:16820587-Sex Characteristics,
pubmed-meshheading:16820587-Signal Transduction,
pubmed-meshheading:16820587-Suppressor of Cytokine Signaling Proteins,
pubmed-meshheading:16820587-Tumor Necrosis Factor Decoy Receptors,
pubmed-meshheading:16820587-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16820587-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2006
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pubmed:articleTitle |
Tumor necrosis factor receptor 1 signaling resistance in the female myocardium during ischemia.
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pubmed:affiliation |
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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