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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1 Suppl
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pubmed:dateCreated |
2006-7-5
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pubmed:abstractText |
Pulmonary hypertension (PH) is a life-threatening disease. Bone marrow cell transplantation is reported to reduce the development of PH by increasing vascular beds in pulmonary circulation. However, adenoviral overexpression of endothelial nitric oxide synthase (eNOS) in the lung is also known to reduce PH. Because mesenchymal stem cells (MSCs) are potential cell sources for neovascularization, the implantation of MSCs overexpressing eNOS (MSCs/eNOS) may further improve the surgical results. We evaluated the efficacy of MSCs/eNOS implantation in monocrotaline (MCT)-induced PH rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
I181-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16820570-Adenoviridae,
pubmed-meshheading:16820570-Animals,
pubmed-meshheading:16820570-Cells, Cultured,
pubmed-meshheading:16820570-DNA, Complementary,
pubmed-meshheading:16820570-Disease Models, Animal,
pubmed-meshheading:16820570-Femoral Vein,
pubmed-meshheading:16820570-Gene Therapy,
pubmed-meshheading:16820570-Genetic Vectors,
pubmed-meshheading:16820570-Humans,
pubmed-meshheading:16820570-Hypertension, Pulmonary,
pubmed-meshheading:16820570-Injections, Intravenous,
pubmed-meshheading:16820570-Male,
pubmed-meshheading:16820570-Mesenchymal Stem Cell Transplantation,
pubmed-meshheading:16820570-Monocrotaline,
pubmed-meshheading:16820570-Nitric Oxide Synthase Type III,
pubmed-meshheading:16820570-Rats,
pubmed-meshheading:16820570-Rats, Sprague-Dawley,
pubmed-meshheading:16820570-Ventricular Dysfunction, Right
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pubmed:year |
2006
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pubmed:articleTitle |
Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension.
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pubmed:affiliation |
Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, Osaka, Japan. tho064@poh.osaka-med.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Evaluation Studies
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