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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1991-12-26
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pubmed:abstractText |
Ligand-activated retinoic acid receptor alpha (RAR alpha) and c-ErbA alpha repress the AP-1-mediated transcriptional activation of the interstitial collagenase gene promoter by specifically decreasing the activity of the AP-1 transcription factor. On the other hand, the v-ErbA oncoprotein fails to repress the AP-1 activity and acts as a dominant negative oncoprotein by overcoming the repression of the AP-1 activity induced by RAR alpha and c-ErbA alpha. This maintenance by v-ErbA of a fully active AP-1 complex is correlated with the abrogation by this same oncogene product of the growth-inhibitory response of chicken embryo fibroblasts to retinoic acid treatment. This new mechanism of action of v-ErbA together with its previously discovered dominant repressor effect on transcription of thyroid hormone-activated target genes may explain the contribution of the v-erbA oncogene to sarcomatogenic and leukemogenic transformation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Microbial Collagenase,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins v-erbA,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-jun,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Retroviridae Proteins, Oncogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
731-40
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1682056-Carrier Proteins,
pubmed-meshheading:1682056-Cell Division,
pubmed-meshheading:1682056-Gene Expression Regulation,
pubmed-meshheading:1682056-HeLa Cells,
pubmed-meshheading:1682056-Humans,
pubmed-meshheading:1682056-Ligands,
pubmed-meshheading:1682056-Microbial Collagenase,
pubmed-meshheading:1682056-Oncogene Proteins v-erbA,
pubmed-meshheading:1682056-Promoter Regions, Genetic,
pubmed-meshheading:1682056-Proto-Oncogene Proteins,
pubmed-meshheading:1682056-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:1682056-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:1682056-Receptors, Retinoic Acid,
pubmed-meshheading:1682056-Receptors, Thyroid Hormone,
pubmed-meshheading:1682056-Retroviridae Proteins, Oncogenic,
pubmed-meshheading:1682056-Tretinoin
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pubmed:year |
1991
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pubmed:articleTitle |
A novel mechanism of action for v-ErbA: abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors.
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pubmed:affiliation |
Immuno-Virologie Moléculaire et Cellulaire Université Claude Bernard Lyon-1/CNRS UMR30, Faculté de Médecine Alexis Carrel, Lyon, France.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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