Linked Life Data

16820313

Source:http://linkedlifedata.com/resource/pubmed/id/16820313

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-7-31
pubmed:abstractText
We previously isolated cDNAs encoding conger eel (Conger myriaster) thyroid hormone (TH) receptors (TRs). In the present study, we investigated the transactivation activities of conger eel TRs treated with THs (3,3',5-triiodo-l-thyronine [T3], l-thyroxine [T4], and 3,3',5'-triiodo-l-thyronine [rT3]), or ligands and activators of other nuclear receptors. Following transient transfection into the Japanese eel (Anguilla japonica) hepatocyte cell line Hepa-E1, the conger eel TRs (cTRs) showed TH-dependent activation of transcription from a TH-responsive promoter. However, no transactivation activity of any of the four cTRs was observed with ligands or activators of other nuclear receptors. Although T3 activation for cTRs is stronger than other THs (T3>T4>rT3), the transactivation sensitivity was different from the activity of cTRs with THs, respectively. Therefore, we conclude that cTRs can act in concert with THs in fish metamorphosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1096-4959
pubmed:author
pubmed:issnType
Print
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
503-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Transactivation activity of thyroid hormone receptors in fish (Conger myriaster) in response to thyroid hormones.
pubmed:affiliation
Department of Fisheries, Graduate School of Agriculture, Kinki University, Nara 631-8505, Japan. yutakakjp@yahoo.co.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't