| pubmed-article:16820091 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16820091 | lifeskim:mentions | umls-concept:C1565860 | lld:lifeskim |
| pubmed-article:16820091 | lifeskim:mentions | umls-concept:C1705323 | lld:lifeskim |
| pubmed-article:16820091 | lifeskim:mentions | umls-concept:C1527249 | lld:lifeskim |
| pubmed-article:16820091 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:16820091 | lifeskim:mentions | umls-concept:C0920269 | lld:lifeskim |
| pubmed-article:16820091 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16820091 | lifeskim:mentions | umls-concept:C1511540 | lld:lifeskim |
| pubmed-article:16820091 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:16820091 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:16820091 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:16820091 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16820091 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16820091 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16820091 | pubmed:dateCreated | 2006-7-5 | lld:pubmed |
| pubmed-article:16820091 | pubmed:abstractText | Cyclooxygenase-2 (COX-2) overexpression and mutations of p53 (a known COX-2 regulator) are inversely associated with microsatellite instability-high (MSI-H) and CpG island methylator phenotype (CIMP) characterized by extensive promoter methylation, is associated with MSI-H. However, no studies have comprehensively examined interrelations between COX-2, p53, MSI, and CIMP. Using MethyLight, we measured DNA methylation in five CIMP-specific gene promoters [CACNA1G, CDKN2A (p16/INK4A), CRABP1, MLH1, and NEUROG1] in relatively unbiased samples of 751 colorectal cancer cases obtained from two large prospective cohorts; 115 (15%) tumors were CIMP-high (> or = 4 of 5 methylated promoters), 251 (33%) were CIMP-low (1 to 3 methylated promoters), and the remaining 385 (51%) were CIMP-0 (no methylated promoters). CIMP-high tumors were much less frequent in COX-2+/p53+ tumors (4.6%) than in COX-2+/p53- tumors (19%; P < .0001), COX-2-/p53+ tumors (17%; P = .04), and COX-2-/p53- tumors (28%; P < .0001). In addition, COX-2+/p53+ tumors were significantly less common in MSI-H CIMP-high tumors (9.7%) than in non-MSI-H CIMP-low/CIMP-0 tumors (44-47%; P < .0001). In conclusion, COX-2 and p53 alterations were synergistically inversely correlated with both MSI-H and CIMP-high. Our data suggest that a combined analysis of COX-2 and p53 may be more useful for the molecular classification of colorectal cancer than either COX-2 or p53 analysis alone. | lld:pubmed |
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| pubmed-article:16820091 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16820091 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16820091 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16820091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16820091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16820091 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16820091 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16820091 | pubmed:issn | 1476-5586 | lld:pubmed |
| pubmed-article:16820091 | pubmed:author | pubmed-author:LodaMassimoM | lld:pubmed |
| pubmed-article:16820091 | pubmed:author | pubmed-author:FuchsCharles... | lld:pubmed |
| pubmed-article:16820091 | pubmed:author | pubmed-author:OginoShujiS | lld:pubmed |
| pubmed-article:16820091 | pubmed:author | pubmed-author:KirknerGregor... | lld:pubmed |
| pubmed-article:16820091 | pubmed:author | pubmed-author:KawasakiTakak... | lld:pubmed |
| pubmed-article:16820091 | pubmed:author | pubmed-author:BrahmandamMoh... | lld:pubmed |
| pubmed-article:16820091 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16820091 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:16820091 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16820091 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16820091 | pubmed:pagination | 458-64 | lld:pubmed |
| pubmed-article:16820091 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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