Linked Life Data

16820005

Source:http://linkedlifedata.com/resource/pubmed/id/16820005

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2006-7-5
pubmed:abstractText
A member of the tumor necrosis factor receptor superfamily, TROY, is expressed in the CNS of embryonic and adult mice. In the present study, we characterized TROY-expressing cells in the embryonic and postnatal forebrain. In the early embryonic forebrain, TROY was highly expressed in nestin-positive neuroepithelial cells and radial glial cells, but not in microtubule-associated protein 2-positive postmitotic neurons. During the late embryonic and postnatal development, expression of TROY was observed in radial glial cells and astrocytes, whereas its expression was not detected in neuronal lineage cells. In addition, TROY was exclusively expressed in Musashi-1-positive multipotent/glial progenitors in the postnatal subventricular zone. To investigate the functions of TROY in neural development, we overexpressed TROY in PC12 cells and established stably expressing cell clones. As expected, the signals from overexpressed TROY were constitutively transduced via the activation of the nuclear factor-kappaB and the c-Jun N-terminal kinase pathways in such clones. In addition, upregulation of negative basic helix-loop-helix transcription factors, HES-5 and Id2 proteins, was observed in the TROY-overexpressing clones. Interestingly, the overexpression of TROY in PC12 cells strongly inhibited nerve growth factor-induced neurite outgrowth with reduction of some markers of differentiated neurons, such as neurofilament 150 kDa and neuron-specific beta-tubulin. These findings suggest that the signaling from TROY regulates neuronal differentiation at least in part.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0953-816X
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3149-60
pubmed:meshHeading
pubmed-meshheading:16820005-Animals, pubmed-meshheading:16820005-Cell Differentiation, pubmed-meshheading:16820005-Central Nervous System, pubmed-meshheading:16820005-Female, pubmed-meshheading:16820005-Intermediate Filament Proteins, pubmed-meshheading:16820005-Mice, pubmed-meshheading:16820005-Mice, Inbred C57BL, pubmed-meshheading:16820005-Microtubule-Associated Proteins, pubmed-meshheading:16820005-Nerve Growth Factor, pubmed-meshheading:16820005-Nerve Tissue Proteins, pubmed-meshheading:16820005-Neuroglia, pubmed-meshheading:16820005-Neurons, pubmed-meshheading:16820005-PC12 Cells, pubmed-meshheading:16820005-Pregnancy, pubmed-meshheading:16820005-RNA-Binding Proteins, pubmed-meshheading:16820005-Rats, pubmed-meshheading:16820005-Receptors, Tumor Necrosis Factor, pubmed-meshheading:16820005-Signal Transduction, pubmed-meshheading:16820005-Stem Cells
pubmed:year
2006
pubmed:articleTitle
Characterization of TROY-expressing cells in the developing and postnatal CNS: the possible role in neuronal and glial cell development.
pubmed:affiliation
Department of Anatomy and Neurobiology, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8509, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't