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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-7-4
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pubmed:abstractText |
Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC(50) of 10.0 microM and 12.2 microM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0918-6158
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pubmed:author |
pubmed-author:AkaoYukihiroY,
pubmed-author:AliZulfiqarZ,
pubmed-author:IinumaMunekazuM,
pubmed-author:IliyaIbrahimI,
pubmed-author:ItoTetsuroT,
pubmed-author:MatsumotoKenjiK,
pubmed-author:MurataHirokoH,
pubmed-author:NakagawaYoshihitoY,
pubmed-author:NozawaYoshinoriY,
pubmed-author:OyamaMasayoshiM,
pubmed-author:TanakaToshiyukiT
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1490-2
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pubmed:meshHeading |
pubmed-meshheading:16819196-Apoptosis,
pubmed-meshheading:16819196-Cell Division,
pubmed-meshheading:16819196-DNA, Neoplasm,
pubmed-meshheading:16819196-DNA Fragmentation,
pubmed-meshheading:16819196-Ferns,
pubmed-meshheading:16819196-HL-60 Cells,
pubmed-meshheading:16819196-Humans,
pubmed-meshheading:16819196-Indonesia,
pubmed-meshheading:16819196-Kinetics,
pubmed-meshheading:16819196-Plant Extracts,
pubmed-meshheading:16819196-Plant Roots,
pubmed-meshheading:16819196-Plant Stems,
pubmed-meshheading:16819196-Stilbenes
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pubmed:year |
2006
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pubmed:articleTitle |
Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells.
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pubmed:affiliation |
Gifu Pharmaceutical University, Japan.
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pubmed:publicationType |
Journal Article
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