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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-12-23
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pubmed:abstractText |
Levels of dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (serotonin, 5-HT) and their metabolites, and the activities of tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH) and monoamine oxidase A and B (MAO-A and MAO-B) have been determined in the rat posterior thalamus after enucleation during postnatal development. DA and 5-HT turnover rate have been measured as 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) accumulation rates after central decarboxylase inhibition by 3-hydroxybenzylhydrazine (NSD-1015). The major changes were an increase in noradrenergic and serotoninergic metabolism in enucleated animals compared with control animals. A decrease of the MAO-A to MAO-B ratio during postnatal development was found.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-hydroxybenzylhydrazine,
http://linkedlifedata.com/resource/pubmed/chemical/5-Hydroxytryptophan,
http://linkedlifedata.com/resource/pubmed/chemical/Aromatic-L-Amino-Acid Decarboxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Biogenic Monoamines,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydroxyphenylalanine,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Monoamine Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptophan Hydroxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase
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pubmed:status |
MEDLINE
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pubmed:issn |
0300-9564
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
231-42
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1681825-5-Hydroxytryptophan,
pubmed-meshheading:1681825-Aging,
pubmed-meshheading:1681825-Animals,
pubmed-meshheading:1681825-Animals, Newborn,
pubmed-meshheading:1681825-Aromatic-L-Amino-Acid Decarboxylases,
pubmed-meshheading:1681825-Biogenic Monoamines,
pubmed-meshheading:1681825-Dihydroxyphenylalanine,
pubmed-meshheading:1681825-Dopamine,
pubmed-meshheading:1681825-Eye Enucleation,
pubmed-meshheading:1681825-Hydrazines,
pubmed-meshheading:1681825-Male,
pubmed-meshheading:1681825-Monoamine Oxidase,
pubmed-meshheading:1681825-Norepinephrine,
pubmed-meshheading:1681825-Rats,
pubmed-meshheading:1681825-Rats, Inbred Strains,
pubmed-meshheading:1681825-Serotonin,
pubmed-meshheading:1681825-Thalamus,
pubmed-meshheading:1681825-Tryptophan Hydroxylase,
pubmed-meshheading:1681825-Tyrosine 3-Monooxygenase
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pubmed:year |
1991
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pubmed:articleTitle |
Effects of neonatal bilateral eye enucleation on postnatal development of the monoamines in posterior thalamus of the rat.
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pubmed:affiliation |
Departamento de Bioquímica, Bromatología y Toxicología, Universidad de Sevilla, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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