Linked Life Data

16816803

Source:http://linkedlifedata.com/resource/pubmed/id/16816803

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-7-3
pubmed:abstractText
Anti-Müllerian hormone (AMH), also called MUllerian inhibiting substance (MIS) is a product of supporting gonadal Sertoli and granulosa cells. Its main physiological role is the induction of regression of Müllerian ducts in male fetuses but it also plays a role in Leydig cell steroidogenesis and in follicular development. It is a member of the transforming growth factor B family and signals through two serine/threonine kinase receptors, only one of whom, type II, is specific. Type I receptors and the intracytoplasmic signaling molecules are shared with the bone morphogenetic family. AMH is positively regulated by SF1, SOX9 and FSH. Testosterone is a powerful downregulator. Males lacking functional AMH or AMH receptor genes do not undergo regression of MUllerian derivatives during fetal life. AMH is an excellent marker of prepubertal testicular function and has gained recognition as a valuable marker of follicular reserve in adult women.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1565-4753
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
347-58
pubmed:dateRevised
2008-4-9
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Testicular anti-Müllerian hormone: history, genetics, regulation and clinical applications.
pubmed:affiliation
Unite de Recherches sur l'Endocrinologie et la Genetique de la Reproduction et du Developpment (INSERM), Universite Paris XI, Clamart, France. josso@inserm.ipsc.u-psud.fr
pubmed:publicationType
Journal Article, Review