16815157

Source:http://linkedlifedata.com/resource/pubmed/id/16815157

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0011615, umls-concept:C0014507, umls-concept:C0178566, umls-concept:C0805586
pubmed:issue	1
pubmed:dateCreated	2006-7-3
pubmed:abstractText	We challenge 3 prevailing concepts in understanding atopic dermatitis using data from epidemiologic studies. First, we show that although atopy is associated with atopic dermatitis to some degree, its importance is not likely to be a simple cause-and-effect relationship, especially at a population level. Our epidemiologic data do not exclude a contributory role for IgE-mediated immunologic processes, especially in those with existing and severe disease. Second, evidence is presented that does not support a straightforward inverse relationship between infections and atopic dermatitis risk. A link, if present, is likely to be more complex, depending critically on the timing and type of infectious exposure. Third, recent evidence suggests that the risk of subsequent childhood asthma is not increased in children with early atopic dermatitis who are not also early wheezers, suggesting a co-manifestation of phenotypes rather than a progressive atopic march. Collectively, these observations underline the importance of epidemiologic studies conducted at a population level to gain a more balanced understanding of the enigma of atopic dermatitis.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/1275002
pubmed:citationSubset	AIM
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	0091-6749
pubmed:author	pubmed-author:FlohrCarstenC, pubmed-author:WilliamsHywelH
pubmed:issnType	Print
pubmed:volume	118
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	209-13
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:16815157-Asthma, pubmed-meshheading:16815157-Dermatitis, Atopic, pubmed-meshheading:16815157-Humans, pubmed-meshheading:16815157-Infection
pubmed:year	2006
pubmed:articleTitle	How epidemiology has challenged 3 prevailing concepts about atopic dermatitis.
pubmed:affiliation	Centre of Evidence-Based Dermatology, University of Nottingham King's Meadow Campus, Lenton Lane, Nottingham NG7 2NR, UK. hywel.williams@nottingham.ac.uk
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't