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pubmed:abstractText |
Amlodipine is a calcium channel blocker (CCB) known to stimulate nitric oxide production from endothelial cells. Whether this ancillary property can be related to the capacity of amlodipine to concentrate and alter the structure of cholesterol-containing membrane bilayers is a matter of investigation. Here, we reasoned that since the endothelial nitric oxide synthase is, in part, expressed in cholesterol-rich plasmalemmal microdomains (e.g., caveolae and rafts), amlodipine could interfere with this specific locale of the enzyme and thereby modulate NO production in endothelial cells.
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pubmed:affiliation |
Unit of Pharmacology and Therapeutics, University of Louvain Medical School, UCL-FATH5349, 53 Avenue E. Mounier, Brussels B-1200, Belgium.
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