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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1991-11-19
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pubmed:abstractText |
Previous studies have shown that some of CNS actions of an endogenous peptide Tyr-MIF-1, are mediated by dopamine (DA) receptors. To study the effect of DA receptor blockade on the antiopiate properties of Tyr-MIF-1, the opiate form of footshock-induced analgesia was elicited in the rat. The nociceptive responses were determined using the hot-plate test (52.5 degrees C). Intraperitoneal pre-treatment with haloperidol (500 micrograms/kg), SCH 23390 (150 micrograms/kg), or spiroperidol (150 micrograms/kg) potentiated the antinociceptive effect of the footshock and blocked the antagonistic action of Tyr-MIF-1 (200 micrograms/kg and 2.0 mg/kg). A dose of haloperidol too small to potentiate the antinociceptive effect of the footshock (100 micrograms/kg) was still able to block the action of Tyr-MIF-1 (200 micrograms/kg). The results suggest that activation of DA receptors mediates the antagonizing effect of Tyr-MIF-1 on the opiate form of footshock-induced analgesia in the rat.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0143-4179
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
281-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1681456-Amino Acid Sequence,
pubmed-meshheading:1681456-Animals,
pubmed-meshheading:1681456-Benzazepines,
pubmed-meshheading:1681456-Dopamine Antagonists,
pubmed-meshheading:1681456-Drug Synergism,
pubmed-meshheading:1681456-Foot,
pubmed-meshheading:1681456-Haloperidol,
pubmed-meshheading:1681456-Hot Temperature,
pubmed-meshheading:1681456-MSH Release-Inhibiting Hormone,
pubmed-meshheading:1681456-Male,
pubmed-meshheading:1681456-Molecular Sequence Data,
pubmed-meshheading:1681456-Naloxone,
pubmed-meshheading:1681456-Pain,
pubmed-meshheading:1681456-Rats,
pubmed-meshheading:1681456-Rats, Inbred Strains,
pubmed-meshheading:1681456-Receptors, Dopamine,
pubmed-meshheading:1681456-Spiperone,
pubmed-meshheading:1681456-Transcutaneous Electric Nerve Stimulation
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pubmed:year |
1991
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pubmed:articleTitle |
Dopamine receptor antagonists block the effect of Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) on the opiate form of footshock-induced analgesia.
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pubmed:affiliation |
Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70146.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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