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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2006-7-31
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pubmed:abstractText |
The design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited potent binding affinity and functional activity at MCH-R1, and good oral bioavailability in rat.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:DwightWesleyW,
pubmed-author:DyckBrianB,
pubmed-author:FisherAndrewA,
pubmed-author:GoodfellowVal SVS,
pubmed-author:GreyJonathanJ,
pubmed-author:HeiseChristopher ECE,
pubmed-author:KiankarimiMehrakM,
pubmed-author:MadanAjayA,
pubmed-author:PetroskiRobertR,
pubmed-author:RowbottomMartin WMW,
pubmed-author:SchwarzDavidD,
pubmed-author:TamiyaJunkoJ,
pubmed-author:VickersTroy DTD,
pubmed-author:WadeWarren SWS,
pubmed-author:WuDongpeiD,
pubmed-author:ZhangMingzhuM
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4450-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
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pubmed:year |
2006
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pubmed:articleTitle |
Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1.
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pubmed:affiliation |
Department of Medicinal Chemistry, Neurocrine Biosciences Inc., San Diego, CA 92130, USA. mrowbottom@neurocrine.com
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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