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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-8-31
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pubmed:abstractText |
Myostatin negatively regulates skeletal muscle growth. Myostatin knockout mice exhibit muscle hypertrophy and decreased interstitial fibrosis. We investigated whether a plasmid expressing a short hairpin interfering RNA (shRNA) against myostatin and transduced using electroporation would increase local skeletal muscle mass.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1099-498X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2006 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1171-81
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16810717-Animals,
pubmed-meshheading:16810717-Base Sequence,
pubmed-meshheading:16810717-Cell Line,
pubmed-meshheading:16810717-Electroporation,
pubmed-meshheading:16810717-Gene Expression,
pubmed-meshheading:16810717-Gene Silencing,
pubmed-meshheading:16810717-Gene Transfer Techniques,
pubmed-meshheading:16810717-Genes, Reporter,
pubmed-meshheading:16810717-Genetic Vectors,
pubmed-meshheading:16810717-Humans,
pubmed-meshheading:16810717-Lac Operon,
pubmed-meshheading:16810717-Male,
pubmed-meshheading:16810717-Mice,
pubmed-meshheading:16810717-Muscle, Skeletal,
pubmed-meshheading:16810717-Myostatin,
pubmed-meshheading:16810717-Plasmids,
pubmed-meshheading:16810717-RNA, Small Interfering,
pubmed-meshheading:16810717-Rats,
pubmed-meshheading:16810717-Rats, Inbred F344,
pubmed-meshheading:16810717-Transfection,
pubmed-meshheading:16810717-Transforming Growth Factor beta
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pubmed:year |
2006
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pubmed:articleTitle |
Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass.
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pubmed:affiliation |
Department of Urology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024, USA. tmagee@labiomed.org
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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