|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5787
|
|
pubmed:dateCreated |
2006-8-4
|
|
pubmed:abstractText |
Axonal guidance and vascular patterning share several guidance cues, including proteins in the netrin family. We demonstrate that netrins stimulate proliferation, migration, and tube formation of human endothelial cells in vitro and that this stimulation is independent of known netrin receptors. Suppression of netrin1a messenger RNA in zebrafish inhibits vascular sprouting, implying a proangiogenic role for netrins during vertebrate development. We also show that netrins accelerate neovascularization in an in vivo model of ischemia and that they reverse neuropathy and vasculopathy in a diabetic murine model. We propose that the attractive vascular and neural guidance functions of netrins offer a unique therapeutic potential.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16809490-11048721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16809490-11239160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16809490-11466388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16809490-12167406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16809490-12960162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16809490-15574733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16809490-15983249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16809490-2557332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16809490-8589427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16809490-8621727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16809490-9152007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16809490-9616228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16809490-9626071
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inducing Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Ntn4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/netrin receptors,
http://linkedlifedata.com/resource/pubmed/chemical/netrin-1,
http://linkedlifedata.com/resource/pubmed/chemical/netrin-2
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1095-9203
|
|
pubmed:author |
pubmed-author:AsaiJunJ,
pubmed-author:ChienChi-BinCB,
pubmed-author:IiMasaakiM,
pubmed-author:KockGerhardus A HGA,
pubmed-author:Larrieu-LahargueFrédericF,
pubmed-author:LiDean YDY,
pubmed-author:LosordoDouglas WDW,
pubmed-author:ParkKye WonKW,
pubmed-author:SilverMarcyM,
pubmed-author:SorensenLise KLK,
pubmed-author:SuhWonheeW,
pubmed-author:SuliArmindaA,
pubmed-author:ThomasKirk RKR,
pubmed-author:ThorneTinaT,
pubmed-author:UrnessLisa DLD,
pubmed-author:WilsonBrent DBD
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
4
|
|
pubmed:volume |
313
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
640-4
|
|
pubmed:dateRevised |
2011-2-21
|
|
pubmed:meshHeading |
pubmed-meshheading:16809490-Angiogenesis Inducing Agents,
pubmed-meshheading:16809490-Animals,
pubmed-meshheading:16809490-Cell Line,
pubmed-meshheading:16809490-Cell Movement,
pubmed-meshheading:16809490-Chemotaxis,
pubmed-meshheading:16809490-DNA, Complementary,
pubmed-meshheading:16809490-Diabetic Angiopathies,
pubmed-meshheading:16809490-Diabetic Neuropathies,
pubmed-meshheading:16809490-Embryo, Nonmammalian,
pubmed-meshheading:16809490-Endothelial Cells,
pubmed-meshheading:16809490-Endothelium, Vascular,
pubmed-meshheading:16809490-Gene Therapy,
pubmed-meshheading:16809490-Humans,
pubmed-meshheading:16809490-Ischemia,
pubmed-meshheading:16809490-Mice,
pubmed-meshheading:16809490-Muscle, Skeletal,
pubmed-meshheading:16809490-Neovascularization, Physiologic,
pubmed-meshheading:16809490-Nerve Growth Factors,
pubmed-meshheading:16809490-Neural Conduction,
pubmed-meshheading:16809490-Receptors, Cell Surface,
pubmed-meshheading:16809490-Tumor Suppressor Proteins,
pubmed-meshheading:16809490-Vascular Endothelial Growth Factor A,
pubmed-meshheading:16809490-Zebrafish
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Netrins promote developmental and therapeutic angiogenesis.
|
|
pubmed:affiliation |
Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
