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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2006-6-30
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pubmed:abstractText |
Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine mRNA expression in the lungs of LPS (25 mg/kg)-treated mice (P < .05). It also showed a tendency for decreased tumor necrosis factor (TNF)-alpha-immunoreactive protein in lung homogenates and significantly decreased TNF-alpha-immunoreactive protein in the serum of LPS-injected mice (P < .05). These results indicate that TGase may be a new therapeutic target in LPS-induced lung inflammation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0190-2148
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pubmed:author |
pubmed-author:ChoiAugustine M KAM,
pubmed-author:ChoiJae ChulJC,
pubmed-author:HamHyoung SukHS,
pubmed-author:HanJounghoJ,
pubmed-author:KimHong PyoHP,
pubmed-author:KimSoo-YoulSY,
pubmed-author:KohWon-JungWJ,
pubmed-author:KwonO JungOJ,
pubmed-author:LeeJongminJ,
pubmed-author:LeeShin-HyeSH,
pubmed-author:SuhGee YoungGY
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
43-53
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pubmed:meshHeading |
pubmed-meshheading:16809220-Administration, Inhalation,
pubmed-meshheading:16809220-Animals,
pubmed-meshheading:16809220-Enzyme Activation,
pubmed-meshheading:16809220-Enzyme Inhibitors,
pubmed-meshheading:16809220-Interleukin-6,
pubmed-meshheading:16809220-Lipopolysaccharides,
pubmed-meshheading:16809220-Male,
pubmed-meshheading:16809220-Mice,
pubmed-meshheading:16809220-Mice, Inbred BALB C,
pubmed-meshheading:16809220-Neutrophils,
pubmed-meshheading:16809220-Peptide Fragments,
pubmed-meshheading:16809220-Pneumonia,
pubmed-meshheading:16809220-RNA, Messenger,
pubmed-meshheading:16809220-Transglutaminases,
pubmed-meshheading:16809220-Tumor Necrosis Factor-alpha
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pubmed:articleTitle |
A Peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice.
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pubmed:affiliation |
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
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pubmed:publicationType |
Journal Article
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