| pubmed-article:168088 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:168088 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:168088 | lifeskim:mentions | umls-concept:C0030350 | lld:lifeskim |
| pubmed-article:168088 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:168088 | lifeskim:mentions | umls-concept:C1882561 | lld:lifeskim |
| pubmed-article:168088 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:168088 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:168088 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:168088 | pubmed:dateCreated | 1975-11-7 | lld:pubmed |
| pubmed-article:168088 | pubmed:abstractText | The spasmolytic effects of papaverine and dibutyryl cyclic AMP (db-cAMP) were compared on isometric contractile responses induced by addition of increasing amounts of external calcium to K+-depolarized or noradrenaline-stimulated rat aorta strips. Papaverine at a concentration active on depolarized strips (3 times 10(-5) moles/1) reduced the maximal contraction (Emax) elicited by Ca2+ in these preparations, while db-cAMP did not. Contrary to what was observed on depolarized aortae, the degree of inhibition of noradrenaline-stimulated strips did not decrease with increasing extracellular calcium concentration (Ca)e. Both db-cAMP and papaverine at a concentration which did not depress Emax (5 times 10(-6) moles/1) potentiated the relaxing effect of high (Ca)e on contractions elicited by noradrenaline. In conclusion, cyclic AMP is probably implicated in the mode of action of papaverine on the noradrenaline-stimulated rat aorta. At a concentration active on depolarized strips, papaverine is also able to impair contractility directly. | lld:pubmed |
| pubmed-article:168088 | pubmed:language | eng | lld:pubmed |
| pubmed-article:168088 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:168088 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:168088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:168088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:168088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:168088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:168088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:168088 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:168088 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:168088 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:168088 | pubmed:author | pubmed-author:StocletJ CJC | lld:pubmed |
| pubmed-article:168088 | pubmed:author | pubmed-author:Demesy-Waelde... | lld:pubmed |
| pubmed-article:168088 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:168088 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:168088 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:168088 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:168088 | pubmed:pagination | 185-94 | lld:pubmed |
| pubmed-article:168088 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:168088 | pubmed:meshHeading | pubmed-meshheading:168088-A... | lld:pubmed |
| pubmed-article:168088 | pubmed:meshHeading | pubmed-meshheading:168088-C... | lld:pubmed |
| pubmed-article:168088 | pubmed:meshHeading | pubmed-meshheading:168088-R... | lld:pubmed |
| pubmed-article:168088 | pubmed:meshHeading | pubmed-meshheading:168088-P... | lld:pubmed |
| pubmed-article:168088 | pubmed:meshHeading | pubmed-meshheading:168088-M... | lld:pubmed |
| pubmed-article:168088 | pubmed:meshHeading | pubmed-meshheading:168088-N... | lld:pubmed |
| pubmed-article:168088 | pubmed:meshHeading | pubmed-meshheading:168088-A... | lld:pubmed |
| pubmed-article:168088 | pubmed:meshHeading | pubmed-meshheading:168088-M... | lld:pubmed |
| pubmed-article:168088 | pubmed:meshHeading | pubmed-meshheading:168088-D... | lld:pubmed |
| pubmed-article:168088 | pubmed:meshHeading | pubmed-meshheading:168088-S... | lld:pubmed |
| pubmed-article:168088 | pubmed:meshHeading | pubmed-meshheading:168088-N... | lld:pubmed |
| pubmed-article:168088 | pubmed:meshHeading | pubmed-meshheading:168088-B... | lld:pubmed |
| pubmed-article:168088 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:168088 | pubmed:articleTitle | Papaverine, cyclic AMP and the dependence of the rat aorta on extracellular calcium. | lld:pubmed |
| pubmed-article:168088 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:168088 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:168088 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:168088 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:168088 | lld:pubmed |
