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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-6-30
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pubmed:abstractText |
In vitro, neural stem cells (NSCs) proliferate as undifferentiated spheroids and differentiate into neurons, astrocytes and oligodendrocytes. These features make NSCs suitable for spinal cord (SC) reconstruction. However, in vivo experiments have demonstrated that in the injured SC transplanted NSCs either remain undifferentiated or differentiate into the astrocytic phenotype. The microenvironment of the injured SC is believed to play a crucial role in driving the differentiation of the engrafted NSCs. Here, we tested the hypothesis that inflammatory cytokines (ICs) may be involved in the restricted differentiation of NSCs after grafting onto the injured SC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0161-6412
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pubmed:author |
pubmed-author:CasalborePatriziaP,
pubmed-author:CenciarelliCarloC,
pubmed-author:D'AlessandrisQuintino GiorgioQG,
pubmed-author:De MariaRuggeroR,
pubmed-author:FalchettiMaria LauraML,
pubmed-author:FernandezEduardoE,
pubmed-author:GereviniValeria Di GiorgioVD,
pubmed-author:LaroccaLuigi MariaLM,
pubmed-author:LiveranaLaurettiL,
pubmed-author:LombardiDario GiuseppeDG,
pubmed-author:MairaGiulioG,
pubmed-author:MontanoNicolaN,
pubmed-author:PalliniRobertoR,
pubmed-author:ParatiEugenioE,
pubmed-author:PeschleCesareC,
pubmed-author:PetrucciGiovannaG,
pubmed-author:Ricci-VitianiLuciaL
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
488-92
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16808877-Animals,
pubmed-meshheading:16808877-Astrocytes,
pubmed-meshheading:16808877-Cell Differentiation,
pubmed-meshheading:16808877-Cytokines,
pubmed-meshheading:16808877-Female,
pubmed-meshheading:16808877-Immunohistochemistry,
pubmed-meshheading:16808877-Interferon-gamma,
pubmed-meshheading:16808877-Interleukin-1,
pubmed-meshheading:16808877-Mice,
pubmed-meshheading:16808877-Neurons,
pubmed-meshheading:16808877-Spinal Cord Injuries,
pubmed-meshheading:16808877-Stem Cell Transplantation,
pubmed-meshheading:16808877-Tumor Necrosis Factor-alpha
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pubmed:year |
2006
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pubmed:articleTitle |
Influence of local environment on the differentiation of neural stem cells engrafted onto the injured spinal cord.
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pubmed:affiliation |
Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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