Linked Life Data

16807544

Source:http://linkedlifedata.com/resource/pubmed/id/16807544

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-8-21
pubmed:abstractText
Glomerulonephritis (GN) is still the most common cause of end-stage renal disease. Accumulation of glomerular macrophages, proliferation of mesangial cells, and deposition of extracellular matrix proteins are pathobiological hallmarks of GN. Pharmacological interventions that can inhibit these insults may be beneficial in the retardation of the progression of GN. Honokiol originally isolated from Magnolia officinalis, shows antioxidative, anti-inflammatory, and antiproliferative activities in a variety of inflammation models. In this study, we first investigated the in vivo effects of honokiol on rat anti-Thy1 nephritis. Anti-Thy1 nephritis was induced in Wistar rats by injecting mouse anti-rat Thy1 antibodies intravenously. Nephritic rats were randomly assigned to receive honokiol (2.5 mg/kg, twice a day) or vehicle and were killed at various time points. Glomerular histology and immunohistopathology and urine protein excretion were studied. Western blotting was conducted for markers of proliferation. Adhesion molecules, chemokine, and extracellular matrix gene expression were evaluated by Northern blotting. Honokiol-treated nephritic rats excreted less urinary protein and had lower glomerular cellularity and sclerosis. The increased intraglomerular proliferating cell nuclear antigen and Akt phosphorylation in nephritic rats could be abolished by the treatment of honokiol. Honokiol also alleviated glomerular monocyte chemoattractant protein-1 and intracellular adhesion molecule-1, similar to type I (alpha1) collagen and fibronectin mRNA levels of nephritic rats. These results indicate that honokiol may have therapeutic potential in mesangial proliferative GN.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0085-2538
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
682-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16807544-Animals, pubmed-meshheading:16807544-Antigens, Thy-1, pubmed-meshheading:16807544-Apoptosis, pubmed-meshheading:16807544-Biphenyl Compounds, pubmed-meshheading:16807544-Cell Proliferation, pubmed-meshheading:16807544-Chemokine CCL2, pubmed-meshheading:16807544-Disease Models, Animal, pubmed-meshheading:16807544-Extracellular Matrix Proteins, pubmed-meshheading:16807544-Gastrointestinal Agents, pubmed-meshheading:16807544-Glomerulonephritis, Membranoproliferative, pubmed-meshheading:16807544-Intercellular Adhesion Molecule-1, pubmed-meshheading:16807544-Lignans, pubmed-meshheading:16807544-Male, pubmed-meshheading:16807544-Proliferating Cell Nuclear Antigen, pubmed-meshheading:16807544-Proteinuria, pubmed-meshheading:16807544-RNA, Messenger, pubmed-meshheading:16807544-Random Allocation, pubmed-meshheading:16807544-Rats, pubmed-meshheading:16807544-Rats, Sprague-Dawley
pubmed:year
2006
pubmed:articleTitle
Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis.
pubmed:affiliation
Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't