Linked Life Data

1680690

Source:http://linkedlifedata.com/resource/pubmed/id/1680690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1991-10-31
pubmed:abstractText
Neuroreceptor imaging is increasing in nuclear medicine. New generations of radioligands will be developed that will allow us to study neurotransmitter systems not studied before. In data interpretation, however, links will have to be made with the number of counts acquired in the image and the real radioactivity in the brain and then, via the specific activity (and known metabolic characteristics), with the concentration of the ligand. From this point, links will have to be made, via kinetic modelling, with receptor density and, if possible, with receptor affinity, with the final link with brain function at a neurophysiological level. In this article several properties of receptor pharmacology and function are discussed that might help with the interpretation. It is argued that there is a complex relationship between the data, as is apparent in the images recorded and the underlying pharmacology of the receptor. Caution should be exercised, however, when in drawing conclusions about the receptor status and the possible implications on pathophysiology.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-6997
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
482-502
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Pharmacological implications for neuroreceptor imaging.
pubmed:affiliation
Department of Nuclear Medicine, Academic Medical Centre, Amsterdam Zuidoost, The Netherlands.
pubmed:publicationType
Journal Article, Review