Linked Life Data

16806846

Source:http://linkedlifedata.com/resource/pubmed/id/16806846

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-8-14
pubmed:abstractText
For homeotic and segment-polarity genes in Drosophila, a switch in gene regulation has been described that distinguishes patterning and maintenance phases. Maintenance of segment and organ primordia involves secondary patterning and differentiation steps, as well as survival factors regulating proliferation and organ size. In a screen for embryonic lethal mutations in the flour beetle Tribolium castaneum, we have recovered two alleles of the knödel gene, which result in short, bag-like embryos. These embryos have severely reduced appendages and differentiate a cuticle that lacks most overt signs of segmentation. In addition, they lack bristles and display defects in the nervous system. Early patterning in knödel mutant embryos is normal up to the extended germ band stage, as indicated by the formation of regular even-skipped (Tc'eve) and wingless (Tc'wg) stripes. Afterwards, however, these patterns degenerate. Similarly, proximo-distal growth and patterning of limbs are nearly normal initially, but limb primordia shrink, and proximo-distal patterns degenerate, during subsequent stages. knödel could be a segment polarity gene required for segment border maintenance in both trunk and appendages. Alternatively, it may have a more general role in tissue or organ maintenance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0925-4773
pubmed:author
pubmed:issnType
Print
pubmed:volume
123
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
430-9
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Maintenance of segment and appendage primordia by the Tribolium gene knödel.
pubmed:affiliation
Institut für Biologie, Friedrich-Alexander-Universität Erlangen, Staudtstrasse 5, 91058 Erlangen, Germany.
pubmed:publicationType
Journal Article