Source:http://linkedlifedata.com/resource/pubmed/id/16806806
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2006-10-18
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| pubmed:abstractText |
Pregnant rats were given 1,3-di-o-tolylguanidine (DTG) by gavage at 0, 10, 20 or 40 mg/kg bw/day on days 6-19 of pregnancy and the pregnancy outcome was determined on day 20 of pregnancy. At 40 mg/kg bw/day, deaths were observed in four out of 24 females. The incidences of females showing mydriasis at 20 and 40 mg/kg bw/day and showing decreased locomotor activity at 40 mg/kg bw/day were significantly increased. Alopecia, bradypnea, prone position and tremor were also observed at mg/kg bw/day. The maternal body weight gain at 20 and 40 mg/kg bw/day and food consumption at 40 mg/kg bw/day were significantly reduced. A significantly decreased weight of the gravid uterus, increased incidence of postimplantation loss, decreased number of live fetuses, and lowered weights of fetuses and placentae were found at 40 mg/kg bw/day. The incidences of the total number of fetuses with external malformations at 40 mg/kg bw/day and with skeletal malformations at 20 and 40 mg/kg bw/day were significantly increased. Significantly higher incidences of fetuses with brachydactyly and short tail and defects of caudal vertebrae, phalanges and metacarpals were observed at 40 mg/kg bw/day. Delayed ossification was also noted at 40 mg/kg bw/day. The data indicate that DTG is teratogenic at maternal toxic doses and the NOAELs of DTG for maternal and developmental toxicity are 10 mg/kg bw/day in rats.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0890-6238
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
672-8
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| pubmed:meshHeading |
pubmed-meshheading:16806806-Abnormalities, Drug-Induced,
pubmed-meshheading:16806806-Animals,
pubmed-meshheading:16806806-Bone and Bones,
pubmed-meshheading:16806806-Cleft Palate,
pubmed-meshheading:16806806-Dose-Response Relationship, Drug,
pubmed-meshheading:16806806-Female,
pubmed-meshheading:16806806-Fetal Death,
pubmed-meshheading:16806806-Fetus,
pubmed-meshheading:16806806-Gestational Age,
pubmed-meshheading:16806806-Guanidines,
pubmed-meshheading:16806806-Hand Deformities, Congenital,
pubmed-meshheading:16806806-Litter Size,
pubmed-meshheading:16806806-Male,
pubmed-meshheading:16806806-Maternal Exposure,
pubmed-meshheading:16806806-Mydriasis,
pubmed-meshheading:16806806-Pregnancy,
pubmed-meshheading:16806806-Rats,
pubmed-meshheading:16806806-Rats, Sprague-Dawley,
pubmed-meshheading:16806806-Rubber,
pubmed-meshheading:16806806-Sex Ratio,
pubmed-meshheading:16806806-Weight Gain,
pubmed-meshheading:16806806-Weight Loss
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Prenatal developmental toxicity study of the basic rubber accelerator, 1,3-di-o-tolylguanidine, in rats.
|
| pubmed:affiliation |
Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, 1-18-1 Kamiyoga, Tokyo, Japan. ema@nihs.go.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|