| pubmed-article:16806124 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16806124 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16806124 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16806124 | lifeskim:mentions | umls-concept:C1515657 | lld:lifeskim |
| pubmed-article:16806124 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:16806124 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16806124 | pubmed:dateCreated | 2006-7-28 | lld:pubmed |
| pubmed-article:16806124 | pubmed:abstractText | We established a PC12 cell line (PC12TH Tet-Off) in which human tyrosine hydroxylase (TH) expression can be negatively controlled by Doxycycline (Dox). First, dopamine (DA)-secretion from PC12TH Tet-Off cells was controlled by Dox-administration in a dose-responsive manner ranging from 0 to 100 ng/ml for 70 days in vitro. Furthermore, Parkinson's disease model of rats receiving encapsulated PC12TH Tet-Off cells displayed a significant decrease of dopamine concentration in the cerebrospinal fluid (CSF) and increase of the number of apomorphine-induced rotations by Dox-administration, as compared to transplanted rats without Dox-administration, although the significant decrease of the reduction ratio of DA concentration in the CSF with Dox-administration was recognized over time. At 2 months post-implantation, concentration of dopamine in the implanted striatum and from the retrieved capsules demonstrated that the control of DA-secretion could be partially achieved for 2 months in vivo. Our results support both the value of cell therapy using Tet-Off system and the technique of encapsulation might be a feasible option for Parkinson's disease especially in resolving the problem of dopamine oversupply in the future, although a more efficient way to control DA-secretion with quicker regulation and much titration of dose should be explored before clinical application. | lld:pubmed |
| pubmed-article:16806124 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16806124 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16806124 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16806124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16806124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16806124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16806124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16806124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16806124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16806124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16806124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16806124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16806124 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16806124 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16806124 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:16806124 | pubmed:author | pubmed-author:MatsuiToshihi... | lld:pubmed |
| pubmed-article:16806124 | pubmed:author | pubmed-author:KobayashiKazu... | lld:pubmed |
| pubmed-article:16806124 | pubmed:author | pubmed-author:MuraokaKenich... | lld:pubmed |
| pubmed-article:16806124 | pubmed:author | pubmed-author:ShingoTetsuro... | lld:pubmed |
| pubmed-article:16806124 | pubmed:author | pubmed-author:DateIsaoI | lld:pubmed |
| pubmed-article:16806124 | pubmed:author | pubmed-author:YasuharaTakao... | lld:pubmed |
| pubmed-article:16806124 | pubmed:author | pubmed-author:MiyoshiYasuyu... | lld:pubmed |
| pubmed-article:16806124 | pubmed:author | pubmed-author:KamedaMasahir... | lld:pubmed |
| pubmed-article:16806124 | pubmed:author | pubmed-author:AgariTakashiT | lld:pubmed |
| pubmed-article:16806124 | pubmed:author | pubmed-author:HayaseHitoshi... | lld:pubmed |
| pubmed-article:16806124 | pubmed:author | pubmed-author:Ji YuanWenW | lld:pubmed |
| pubmed-article:16806124 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16806124 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:16806124 | pubmed:volume | 1102 | lld:pubmed |
| pubmed-article:16806124 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16806124 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16806124 | pubmed:pagination | 1-11 | lld:pubmed |
| pubmed-article:16806124 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16806124 | pubmed:meshHeading | pubmed-meshheading:16806124... | lld:pubmed |
| pubmed-article:16806124 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16806124 | pubmed:articleTitle | Control of dopamine-secretion by Tet-Off system in an in vivo model of parkinsonian rat. | lld:pubmed |
| pubmed-article:16806124 | pubmed:affiliation | Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science, Japan. | lld:pubmed |
| pubmed-article:16806124 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16806124 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16806124 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16806124 | lld:pubmed |
