Source:http://linkedlifedata.com/resource/pubmed/id/16803988
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2006-6-28
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pubmed:abstractText |
CARF was first cloned as a novel binding partner of ARF from a yeast-interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. We demonstrate that p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0077-8923
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
1067
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
217-9
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pubmed:meshHeading |
pubmed-meshheading:16803988-Animals,
pubmed-meshheading:16803988-Cell Aging,
pubmed-meshheading:16803988-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:16803988-Humans,
pubmed-meshheading:16803988-Models, Biological,
pubmed-meshheading:16803988-Tumor Suppressor Protein p14ARF,
pubmed-meshheading:16803988-Tumor Suppressor Protein p53
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pubmed:year |
2006
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pubmed:articleTitle |
CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints.
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pubmed:affiliation |
National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Ibaraki, Japan. s-kaul@aist.go.jp
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pubmed:publicationType |
Journal Article,
Review
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