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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1991-10-18
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pubmed:abstractText |
We have previously demonstrated that depletion of Thy 1+ cells impairs the capacity of C57BL/6J, H-2b bone marrow cells, BMC, and BALB/cxC57BL/6J F1 BMC and spleen cells (SC) to establish mixed lymphoid chimerism and tolerance for donor-specific skin grafts in sublethally irradiated (240 cGy x3) BALB/c, H-2d hosts. In the present studies incubation with anti Ly2.2 + C markedly reduced the capacity of BALB/cxC57BL/6J, F1 SC to induce tolerance and chimerism (P less than .001). Incubation with anti-L3T4 + C had an inhibitory effect of borderline significance (P less than .04). Incubation with L-leucyl-L-leucine methyl ester (which removes NK cells, Tc, and precursor Tc) had no effect on the capacity of either C57BL/6J BMC or BALB/cxC57BL/6J F1 BMC or SC to establish chimerism and induce skin graft tolerance. These results suggest that tolerance-promoting Thy 1+ cells are not cytotoxic T cells. Both Ly2+ noncytotoxic CD8+ and L3T4+ noncytotoxic CD4+ cells may be involved. Alternatively the requisite Thy 1+ cells may be immature T cells that express both Ly2 and L3T4.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Thy-1,
http://linkedlifedata.com/resource/pubmed/chemical/Dipeptides,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/leucyl-leucine-methyl ester
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0041-1337
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
526-30
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1680254-Animals,
pubmed-meshheading:1680254-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1680254-Antigens, Surface,
pubmed-meshheading:1680254-Antigens, Thy-1,
pubmed-meshheading:1680254-Bone Marrow Transplantation,
pubmed-meshheading:1680254-Dipeptides,
pubmed-meshheading:1680254-H-2 Antigens,
pubmed-meshheading:1680254-Histocompatibility,
pubmed-meshheading:1680254-Immune Tolerance,
pubmed-meshheading:1680254-Mice,
pubmed-meshheading:1680254-Mice, Inbred Strains,
pubmed-meshheading:1680254-Skin Transplantation,
pubmed-meshheading:1680254-T-Lymphocytes,
pubmed-meshheading:1680254-Transplantation, Homologous,
pubmed-meshheading:1680254-Whole-Body Irradiation
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pubmed:year |
1991
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pubmed:articleTitle |
Thy 1+ donor cells that promote allograft tolerance in sublethally irradiated MHC-disparate hosts.
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pubmed:affiliation |
University of Kansas Medical Center, Kansas City 66103.
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pubmed:publicationType |
Journal Article
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