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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-8-18
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pubmed:abstractText |
Microvascular disorders are relevant in systemic sclerosis (SSc). Hyperviscosity, due to alterations of blood cells and plasma components, may play a role in the pathogenesis of microcirculatory disorders. An impaired availability of nitric oxide, related to polymorphisms in NOS3, the gene for endothelial cell nitric oxide synthase, might influence erythrocyte deformability. We undertook this study to investigate the hemorheologic profile in SSc and the role of NOS3 polymorphisms in modulating the hemorheologic status of SSc patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0004-3591
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pubmed:author |
pubmed-author:AbbateRosannaR,
pubmed-author:BolliPaolaP,
pubmed-author:CerinicMarco MatucciMM,
pubmed-author:CinelliMarinaM,
pubmed-author:ConfortiMaria LetiziaML,
pubmed-author:FatiniCinziaC,
pubmed-author:GuiducciSerenaS,
pubmed-author:ManniniLuciaL,
pubmed-author:PignoneAlberto MoggiAM,
pubmed-author:RogaiVeronicaV,
pubmed-author:SticchiElenaE
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2263-70
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pubmed:meshHeading |
pubmed-meshheading:16802365-Aged,
pubmed-meshheading:16802365-Alleles,
pubmed-meshheading:16802365-Blood Circulation,
pubmed-meshheading:16802365-Blood Flow Velocity,
pubmed-meshheading:16802365-Blood Viscosity,
pubmed-meshheading:16802365-DNA,
pubmed-meshheading:16802365-Erythrocyte Deformability,
pubmed-meshheading:16802365-Female,
pubmed-meshheading:16802365-Gene Expression Regulation,
pubmed-meshheading:16802365-Genetic Predisposition to Disease,
pubmed-meshheading:16802365-Humans,
pubmed-meshheading:16802365-Male,
pubmed-meshheading:16802365-Microcirculation,
pubmed-meshheading:16802365-Middle Aged,
pubmed-meshheading:16802365-Multivariate Analysis,
pubmed-meshheading:16802365-Nitric Oxide Synthase Type III,
pubmed-meshheading:16802365-Polymorphism, Genetic,
pubmed-meshheading:16802365-Scleroderma, Systemic
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pubmed:year |
2006
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pubmed:articleTitle |
Hemorheologic profile in systemic sclerosis: role of NOS3 -786T > C and 894G >T polymorphisms in modulating both the hemorheologic parameters and the susceptibility to the disease.
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pubmed:affiliation |
Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, 50134 Florence, Italy. cinziafatini@hotmail.com
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pubmed:publicationType |
Journal Article
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