rdf:type |
|
lifeskim:mentions |
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pubmed:issue |
1
|
pubmed:dateCreated |
2006-7-4
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pubmed:abstractText |
Eisenmenger syndrome is characterized by the development of pulmonary arterial hypertension with consequent intracardiac right-to-left shunt and hypoxemia in patients with preexisting congenital heart disease. Because Eisenmenger syndrome is associated with increased endothelin expression, patients may benefit from endothelin receptor antagonism. Theoretically, interventions that have some effect on the systemic vascular bed could worsen the shunt and increase hypoxemia.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Jul
|
pubmed:issn |
1524-4539
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
4
|
pubmed:volume |
114
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
48-54
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16801459-Adult,
pubmed-meshheading:16801459-Antihypertensive Agents,
pubmed-meshheading:16801459-Double-Blind Method,
pubmed-meshheading:16801459-Eisenmenger Complex,
pubmed-meshheading:16801459-Exercise Tolerance,
pubmed-meshheading:16801459-Female,
pubmed-meshheading:16801459-Hemodynamics,
pubmed-meshheading:16801459-Humans,
pubmed-meshheading:16801459-Male,
pubmed-meshheading:16801459-Middle Aged,
pubmed-meshheading:16801459-Oxygen,
pubmed-meshheading:16801459-Receptors, Endothelin,
pubmed-meshheading:16801459-Sulfonamides,
pubmed-meshheading:16801459-Treatment Outcome
|
pubmed:year |
2006
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pubmed:articleTitle |
Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study.
|
pubmed:affiliation |
Istituto di Cardiologia, Università di Bologna, Via Massarenti, 9 IT-40138, Bologna, Italy. nazzareno.galie@unibo.it
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|