Linked Life Data

1680012

Source:http://linkedlifedata.com/resource/pubmed/id/1680012

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-10-24
pubmed:abstractText
Heterologous heat shock proteins (hsps) are antigens in many infectious diseases involving bacteria, parasites and perhaps even fungi. T and B lymphocytes recognize multiple epitopes on these proteins. Recently, lymphocytes expressing gamma delta T cell receptors (gamma delta cells) were also found to react with hsps that are members of the 60 kiloDalton (kDa) family. The response of gamma delta cells to hsp 60 differs from that of alpha beta T cells and B cells in several ways: the frequency of reactive gamma delta clones is high. Many clones recognize the same portion of this protein instead of scattered antigenic epitopes; and most gamma delta cells that react with the mycobacterial hsp-60 homolog are also stimulated by the autologous homolog. Perhaps, such (self) hsp-reactive gamma delta populations function by distinguishing stressed from not stressed states in autologous cells and tissues, rather than by discriminating 'self' and 'non-self'.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1044-5323
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Possible links between immune system and stress response: the role of gamma delta T lymphocytes.
pubmed:affiliation
National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
pubmed:publicationType
Journal Article, Comparative Study, Review