Linked Life Data

1679991

Source:http://linkedlifedata.com/resource/pubmed/id/1679991

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-10-21
pubmed:abstractText
Pneumocystis carinii is the most important pulmonary pathogen in patients with the acquired immunodeficiency syndrome, but host defenses against P. carinii are not well characterized. We recently reported an experimental model of P. carinii infection, in which mice selectively depleted of CD4+ lymphocytes develop pulmonary infection after inoculation with P. carinii. In the current study, we compared lung inflammatory responses to P. carinii inoculation in CD4-depleted mice and in normal mice in order to further characterize host defenses against P. carinii. We hypothesized that depletion of CD4+ lymphocytes would prevent recruitment and activation of inflammatory cells in the lungs of these mice, allowing progressive infection with P. carinii. We found that CD4-depleted mice were unable to recruit CD4+ lymphocytes into their lungs and developed progressive infection with P. carinii, but mounted exuberant inflammatory responses to the organisms. These inflammatory responses were characterized by perivascular infiltration with mononuclear cells, increases in cell numbers in bronchoalveolar lavage (particularly CD8+ lymphocytes), and activation of alveolar macrophages (enhanced Ia antigen expression). In contrast, normal mice recruited CD4+ lymphocytes into their lungs and eliminated organisms with only minimal inflammatory responses. We conclude that depletion of CD4+ lymphocytes does not prevent the recruitment and activation of inflammatory cells in the lung. These inflammatory responses occur by mechanisms independent of CD4+ lymphocytes and are insufficient to provide effective host defense against P. carinii.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1044-1549
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
186-97
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:1679991-Animals, pubmed-meshheading:1679991-Antigens, CD8, pubmed-meshheading:1679991-Antigens, Differentiation, T-Lymphocyte, pubmed-meshheading:1679991-B-Lymphocytes, pubmed-meshheading:1679991-CD4-Positive T-Lymphocytes, pubmed-meshheading:1679991-Flow Cytometry, pubmed-meshheading:1679991-Histocompatibility Antigens Class II, pubmed-meshheading:1679991-Inflammation, pubmed-meshheading:1679991-Interleukin-1, pubmed-meshheading:1679991-Leukocyte Count, pubmed-meshheading:1679991-Lymphocyte Depletion, pubmed-meshheading:1679991-Macrophage Activation, pubmed-meshheading:1679991-Mice, pubmed-meshheading:1679991-Mice, Inbred BALB C, pubmed-meshheading:1679991-Pneumocystis, pubmed-meshheading:1679991-Pneumonia, Pneumocystis, pubmed-meshheading:1679991-T-Lymphocytes, Helper-Inducer
pubmed:year
1991
pubmed:articleTitle
Inflammatory responses to Pneumocystis carinii in mice selectively depleted of helper T lymphocytes.
pubmed:affiliation
Respiratory Care Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't