rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
7
|
pubmed:dateCreated |
2006-7-10
|
pubmed:abstractText |
Serotonin (5-hydroxytryptamine [5-HT]) is a key modulator of gut function that in excess causes nausea, vomiting, and diarrhea. We recently showed that patients with post-infective irritable bowel syndrome have increased postprandial release of 5-HT associated with low-grade T-cell mediated inflammation. Celiac disease is another common disease in which a T-cell enteropathy is associated with increased mucosal 5-HT levels. Our aim was to determine how this inflammatory lesion influenced 5-HT bioavailability and how changes in 5-HT related to the symptoms of nausea, vomiting, and diarrhea seen in untreated celiac patients.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
1542-3565
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
4
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
874-81
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:16797248-Adolescent,
pubmed-meshheading:16797248-Adult,
pubmed-meshheading:16797248-Aged,
pubmed-meshheading:16797248-Case-Control Studies,
pubmed-meshheading:16797248-Celiac Disease,
pubmed-meshheading:16797248-Duodenum,
pubmed-meshheading:16797248-Dyspepsia,
pubmed-meshheading:16797248-Female,
pubmed-meshheading:16797248-Humans,
pubmed-meshheading:16797248-Hydroxyindoleacetic Acid,
pubmed-meshheading:16797248-Intestinal Mucosa,
pubmed-meshheading:16797248-Male,
pubmed-meshheading:16797248-Middle Aged,
pubmed-meshheading:16797248-Postprandial Period,
pubmed-meshheading:16797248-Serotonin
|
pubmed:year |
2006
|
pubmed:articleTitle |
Abnormalities of serotonin metabolism and their relation to symptoms in untreated celiac disease.
|
pubmed:affiliation |
Division of Gastroenterology, School of Medical and Surgical Sciences, University Hospital, Nottingham, United Kingdom.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|