Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1991-10-17
|
| pubmed:abstractText |
Proto-oncogene restriction fragment length polymorphisms (RFLPs) were investigated in a group of 23 patients with squamous cell carcinomas of the larynx. The frequency of the rare 5 kb c-mos allele was significantly higher than that observed in control groups of patients with colorectal neoplasms or lymphoproliferative disorders. In addition, the 2 patients heterozygous at the c-mos locus (TC-8 and TC-10) were the only 2 of our series of develop multiple malignancies. Also, the 10 kb L-myc allele was remarkably more represented in patients with laryngeal carcinoma when compared to controls. These findings suggest that c-mos and L-myc RFLPs might be helpful in identifying those individuals who are at a higher risk of developing laryngeal carcinomas. Single allele amplification of L-myc, c-myb and c-mos proto-oncogenes, with no concomitant mRNA hyperexpression, were observed in 3 cases. The results obtained seem to rule out a direct pathogenetic role of these proto-oncogenes and suggest that the amplification of other closely linked genes, located on chromosomes 1, 6 and 8, respectively, may be causally associated with the development of these tumors. No allelic deletions at the c-myb locus were observed, whereas a loss of a c-Ha-ras-1 allele was demonstrated in one of the 11 heterozygous patients. Thus, the analysis of polymorphic proto-oncogenes in laryngeal carcinomas allowed us to identify a group of genetic abnormalities (chromosomes 1, 6 and 8 gene amplifications and c-Ha-ras-1 deletions) which may be involved in the development or progression of these tumors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0937-4477
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
248
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
279-85
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1679639-Aged,
pubmed-meshheading:1679639-Aged, 80 and over,
pubmed-meshheading:1679639-Alleles,
pubmed-meshheading:1679639-Blotting, Northern,
pubmed-meshheading:1679639-Blotting, Southern,
pubmed-meshheading:1679639-Carcinoma, Squamous Cell,
pubmed-meshheading:1679639-Chromosome Mapping,
pubmed-meshheading:1679639-DNA Probes,
pubmed-meshheading:1679639-Gene Amplification,
pubmed-meshheading:1679639-Genes, mos,
pubmed-meshheading:1679639-Genes, myc,
pubmed-meshheading:1679639-Genes, ras,
pubmed-meshheading:1679639-Hodgkin Disease,
pubmed-meshheading:1679639-Humans,
pubmed-meshheading:1679639-Laryngeal Neoplasms,
pubmed-meshheading:1679639-Lymphoma, Non-Hodgkin,
pubmed-meshheading:1679639-Middle Aged,
pubmed-meshheading:1679639-Nucleic Acid Hybridization,
pubmed-meshheading:1679639-Oncogenes,
pubmed-meshheading:1679639-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:1679639-Proto-Oncogenes
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Proto-oncogene allelic variations in human squamous cell carcinomas of the larynx.
|
| pubmed:affiliation |
Division of Experimental Oncology I, Centro di Riferimento Oncologico, Aviano, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|