Source:http://linkedlifedata.com/resource/pubmed/id/16796362
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2006-6-26
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pubmed:abstractText |
This research was aimed to characterize microemulsion systems of isopropyl palmitate (IPP), water, and 2:1 Brij 97 and 1-butanol by different experimental techniques. A pseudoternary phase diagram was constructed using water titration method. At 45% wt/wt surfactant system, microemulsions containing various ratios of water and IPP were prepared and identified by electrical conductivity, viscosity, differential scanning calorimetry (DSC), cryo-field emission scanning electron microscopy (cryo-FESEM) and nuclear magnetic resonance (NMR). The results from conductivity and viscosity suggested a percolation transition from water-in-oil (water/oil) to oil-in-water (oil/water) microemulsions at 30% wt/wt water. From DSC results, the exothermic peak of water and the endothermic peak of IPP indicated that the transition of water/oil to oil/water microemulsions occurred at 30% wt/wt water. Cryo-FESEM photomicrographs revealed globular structures of microemulsions at higher than 15% wt/wt water. In addition, self-diffusion coefficients determined by NMR reflected that the diffusability of water increased at higher than 35% wt/wt water, while that of IPP was in reverse. Therefore, the results from all techniques are in good agreement and indicate that the water/oil and oil/water transition point occurred in the range of 30% to 35% wt/wt water.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-Butanol,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Carriers,
http://linkedlifedata.com/resource/pubmed/chemical/Emulsions,
http://linkedlifedata.com/resource/pubmed/chemical/Excipients,
http://linkedlifedata.com/resource/pubmed/chemical/Palmitates,
http://linkedlifedata.com/resource/pubmed/chemical/Pharmaceutical Vehicles,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Oils,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Water,
http://linkedlifedata.com/resource/pubmed/chemical/isopropyl palmitate,
http://linkedlifedata.com/resource/pubmed/chemical/polyethylene glycol oleyl ether
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pubmed:status |
MEDLINE
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pubmed:issn |
1530-9932
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
E45
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pubmed:dateRevised |
2010-12-28
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pubmed:meshHeading |
pubmed-meshheading:16796362-1-Butanol,
pubmed-meshheading:16796362-Drug Carriers,
pubmed-meshheading:16796362-Emulsions,
pubmed-meshheading:16796362-Excipients,
pubmed-meshheading:16796362-Molecular Conformation,
pubmed-meshheading:16796362-Palmitates,
pubmed-meshheading:16796362-Pharmaceutical Vehicles,
pubmed-meshheading:16796362-Phase Transition,
pubmed-meshheading:16796362-Plant Oils,
pubmed-meshheading:16796362-Polyethylene Glycols,
pubmed-meshheading:16796362-Water
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pubmed:year |
2006
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pubmed:articleTitle |
Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitate/water/Brij 97:1-butanol.
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pubmed:affiliation |
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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