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rdf:type |
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lifeskim:mentions |
umls-concept:C0022802,
umls-concept:C0333463,
umls-concept:C0443286,
umls-concept:C1306673,
umls-concept:C1441616,
umls-concept:C1514811,
umls-concept:C1522492,
umls-concept:C1561577,
umls-concept:C1706462,
umls-concept:C2603343,
umls-concept:C2936349
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pubmed:issue |
3
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pubmed:dateCreated |
1991-10-10
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pubmed:abstractText |
The authors examined 10 patients with Gerstmann-Sträussler syndrome or Creutzfeldt-Jakob disease and 10 with Alzheimer's disease (AD). Immunohistochemistry using anti-prion protein (PrP) and anti-beta/A4 protein (beta/A4) coupled with formic acid pretreatment could detect Congophilic and non-Congophilic deposits. Prion protein deposits were classified into five types and compared with types of beta/A4 deposits. Kuru plaques with multicentric cores and fine granular deposits were a characteristic feature of PrP deposits. Some types of PrP or beta/A4 deposits depend on the anatomic sites. To clarify the relationship of microglia and astrocytes to PrP or beta/A4 deposits, double-immunostaining method was performed. In both kuru and senile plaques, microglia were closely linked to the Congophilic plaques. Astrocytes, however, extended their processes toward the plaques even in the non-Congophilic plaques. These observations strongly suggest that similar glial association with plaque formation may be involved in both kuru and senile plaques, although the amyloid core proteins differ.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-13907612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-1669689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-1690867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-1977900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-2058362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-2180366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-2296379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-2441141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-2460518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-2464938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-2502927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-2596262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-2642985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-2668786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-2677252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-2808689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-2864910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-3059748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-3112659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-3159021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-3289400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-3399080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-3670729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-382976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-3994315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-6182185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-6198232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-6375662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-6537788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-6801762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-7190246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1679596-90074
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-9440
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
139
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
589-98
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1679596-Alzheimer Disease,
pubmed-meshheading:1679596-Amyloid,
pubmed-meshheading:1679596-Astrocytes,
pubmed-meshheading:1679596-Creutzfeldt-Jakob Syndrome,
pubmed-meshheading:1679596-Gerstmann-Straussler-Scheinker Disease,
pubmed-meshheading:1679596-Humans,
pubmed-meshheading:1679596-Immunohistochemistry,
pubmed-meshheading:1679596-Kuru,
pubmed-meshheading:1679596-Neuroglia,
pubmed-meshheading:1679596-PrPSc Proteins,
pubmed-meshheading:1679596-Prions,
pubmed-meshheading:1679596-Viral Proteins
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pubmed:year |
1991
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pubmed:articleTitle |
A comparative immunohistochemical study of Kuru and senile plaques with a special reference to glial reactions at various stages of amyloid plaque formation.
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pubmed:affiliation |
Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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