Linked Life Data

16794911

Source:http://linkedlifedata.com/resource/pubmed/id/16794911

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-12-13
pubmed:abstractText
Open abdominal aortic aneurysm (AAA) repair is a common surgical procedure associated with high mortality rates. Our objective was to describe the use of in-hospital cardiac medical therapy among patients undergoing open AAA repair and to examine the effect of perioperative cardiac medical therapy on in-hospital mortality. We examined clinical data and in-hospital medication use among 223 patients who underwent open AAA repair at three North American hospitals, all of which used the Transition resource and cost accounting system. Medication use was described [angiotensin converting enzyme (ACE) inhibitors, aspirin, ss-blockers, and statins] within the cohort at five specific periods of time: presurgery, day of surgery, 1 day after surgery, postsurgery, and discharge. We then performed a matched case-control study where cases were defined as patients who died in-hospital. We compared medication use between cases and controls to assess its impact on in-hospital mortality. Most patients were elderly (mean age 72.5 +/- 9.8 years), 70.4% were male, and in-hospital mortality within the cohort was 10.8%. Medication use in all periods of administration was low. ss-Blocker use was highest among all classes on the day of surgery, with 20.6% of patients undergoing AAA repair receiving the medication. Less than 50% of patients received any of the medications at discharge. After adjusting for baseline differences, perioperative ACE inhibitor use showed a trend toward a protective effect [odds ratio (OR) = 0.09, 95% confidence interval (CI) 0.01-1.31, p = 0.08], and perioperative ss-blocker use was significantly associated with a decrease in mortality (OR = 0.07, 95% CI 0.01-0.87, p = 0.04). Cardiac medical therapy among patients undergoing AAA repair is low throughout all periods of hospitalization. ACE inhibitor and ss-blocker use may be associated with decreased in-hospital mortality.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0890-5096
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
569-76
pubmed:meshHeading
pubmed-meshheading:16794911-Adrenergic beta-Antagonists, pubmed-meshheading:16794911-Aged, pubmed-meshheading:16794911-Angiotensin-Converting Enzyme Inhibitors, pubmed-meshheading:16794911-Aortic Aneurysm, Abdominal, pubmed-meshheading:16794911-Aspirin, pubmed-meshheading:16794911-Case-Control Studies, pubmed-meshheading:16794911-Cohort Studies, pubmed-meshheading:16794911-Drug Utilization, pubmed-meshheading:16794911-Female, pubmed-meshheading:16794911-Hospital Mortality, pubmed-meshheading:16794911-Hospitalization, pubmed-meshheading:16794911-Humans, pubmed-meshheading:16794911-Hydroxymethylglutaryl-CoA Reductase Inhibitors, pubmed-meshheading:16794911-Logistic Models, pubmed-meshheading:16794911-Male, pubmed-meshheading:16794911-North America, pubmed-meshheading:16794911-Odds Ratio, pubmed-meshheading:16794911-Perioperative Care, pubmed-meshheading:16794911-Physician's Practice Patterns, pubmed-meshheading:16794911-Platelet Aggregation Inhibitors, pubmed-meshheading:16794911-Research Design, pubmed-meshheading:16794911-Time Factors, pubmed-meshheading:16794911-Treatment Outcome, pubmed-meshheading:16794911-Vascular Surgical Procedures
pubmed:year
2006
pubmed:articleTitle
Cardiac medical therapy among patients undergoing abdominal aortic aneurysm repair.
pubmed:affiliation
Division of Cardiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Multicenter Study