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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2006-7-12
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pubmed:abstractText |
Alterations in endoplasmic reticulum (ER) cholesterol are fundamental for a variety of cellular processes such as the regulation of lipid homeostasis or efficient protein degradation. We show that reduced levels of cellular sterols cause a delayed ER-to-Golgi transport of the secretory cargo membrane protein ts-O45-G and a relocation to the ER of an endogenous protein cycling between the ER and the Golgi complex. Transport inhibition is characterized by a delay in the accumulation of ts-O45-G in ER-exit sites (ERES) and correlates with a reduced mobility of ts-O45-G within ER membranes. A simple mathematical model describing the kinetics of ER-exit predicts that reduced cargo loading to ERES and not the reduced mobility of ts-O45-G accounts for the delayed ER-exit and arrival at the Golgi. Consistent with this, membrane turnover of the COPII component Sec23p is delayed in sterol-depleted cells. Altogether, our results demonstrate the importance of sterol levels in COPII mediated ER-export.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794576-10412983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794576-10588952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794576-10619424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794576-10806480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794576-10825291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794576-10890900,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16794576-10982397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16794576-11099405,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16794576-11884515,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16794576-9685263
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/G protein, vesicular stomatitis...,
http://linkedlifedata.com/resource/pubmed/chemical/LMAN1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mannose-Binding Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Monomeric GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SAR1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SAR1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SEC23A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2953-65
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16794576-COP-Coated Vesicles,
pubmed-meshheading:16794576-Cholesterol,
pubmed-meshheading:16794576-Endoplasmic Reticulum,
pubmed-meshheading:16794576-Golgi Apparatus,
pubmed-meshheading:16794576-HeLa Cells,
pubmed-meshheading:16794576-Humans,
pubmed-meshheading:16794576-Intracellular Membranes,
pubmed-meshheading:16794576-Kinetics,
pubmed-meshheading:16794576-Mannose-Binding Lectins,
pubmed-meshheading:16794576-Membrane Glycoproteins,
pubmed-meshheading:16794576-Membrane Proteins,
pubmed-meshheading:16794576-Models, Biological,
pubmed-meshheading:16794576-Monomeric GTP-Binding Proteins,
pubmed-meshheading:16794576-Protein Transport,
pubmed-meshheading:16794576-Recombinant Fusion Proteins,
pubmed-meshheading:16794576-Vesicular Transport Proteins,
pubmed-meshheading:16794576-Viral Envelope Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
Sterols regulate ER-export dynamics of secretory cargo protein ts-O45-G.
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