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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-6-23
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pubmed:abstractText |
Hyperandrogenism is a central feature of the polycystic ovary syndrome (PCOS) and might worsen insulin resistance (IR) often seen in PCOS. Androgens act through the androgen receptor (AR). A polymorphic CAG repeat sequence within the AR gene was reported to modulate its transactivation activity. Therefore, we investigated a putative interaction between testosterone and the CAG repeat length polymorphism with respect to IR.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0804-4643
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pubmed:author |
pubmed-author:BrabantGeorgG,
pubmed-author:GromollJörgJ,
pubmed-author:HoffmannKurtK,
pubmed-author:JürgensAnnetteA,
pubmed-author:MöhligMatthiasM,
pubmed-author:PfeifferAndreas F HAF,
pubmed-author:SchöflChristofC,
pubmed-author:SchüringAndreasA,
pubmed-author:SchillThiloT,
pubmed-author:SchlösserHans WHW,
pubmed-author:SprangerJoachimJ,
pubmed-author:WeickertMartin OMO
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pubmed:issnType |
Print
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pubmed:volume |
155
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-30
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pubmed:meshHeading |
pubmed-meshheading:16793958-Adult,
pubmed-meshheading:16793958-Alleles,
pubmed-meshheading:16793958-Cohort Studies,
pubmed-meshheading:16793958-Female,
pubmed-meshheading:16793958-Glucose Tolerance Test,
pubmed-meshheading:16793958-Homeostasis,
pubmed-meshheading:16793958-Humans,
pubmed-meshheading:16793958-Insulin Resistance,
pubmed-meshheading:16793958-Polycystic Ovary Syndrome,
pubmed-meshheading:16793958-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:16793958-Receptors, Androgen,
pubmed-meshheading:16793958-Regression Analysis,
pubmed-meshheading:16793958-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:16793958-Testosterone
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pubmed:year |
2006
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pubmed:articleTitle |
The androgen receptor CAG repeat modifies the impact of testosterone on insulin resistance in women with polycystic ovary syndrome.
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pubmed:affiliation |
Department of Endocrinology, Diabetes and Nutrition, Charité-University Medicine Berlin, Berlin, Germany.
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pubmed:publicationType |
Journal Article
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