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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-6-22
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pubmed:abstractText |
Recent studies have described reduced absorption of certain protease inhibitors when administered with agents known to increase gastric pH. No clinically significant interactions between saquinavir absorption and gastric pH have previously been shown. We evaluated the effect of omeprazole, a proton-pump-inhibitor, on the pharmacokinetics of the recently developed saquinavir-500 mg formulation co-administered with ritonavir.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0269-9370
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1401-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16791014-Adolescent,
pubmed-meshheading:16791014-Adult,
pubmed-meshheading:16791014-Anti-Ulcer Agents,
pubmed-meshheading:16791014-Drug Interactions,
pubmed-meshheading:16791014-Drug Therapy, Combination,
pubmed-meshheading:16791014-Female,
pubmed-meshheading:16791014-HIV Protease Inhibitors,
pubmed-meshheading:16791014-Humans,
pubmed-meshheading:16791014-Male,
pubmed-meshheading:16791014-Middle Aged,
pubmed-meshheading:16791014-Omeprazole,
pubmed-meshheading:16791014-Proton Pumps,
pubmed-meshheading:16791014-Ritonavir,
pubmed-meshheading:16791014-Saquinavir
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pubmed:year |
2006
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pubmed:articleTitle |
Effect of omeprazole on the pharmacokinetics of saquinavir-500 mg formulation with ritonavir in healthy male and female volunteers.
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pubmed:affiliation |
Chelsea and Westminster Hospital, London, UK. awinston@imperial.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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