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rdf:type |
|
|
lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-6-22
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pubmed:abstractText |
The intensity of replication of CCR5-using HIV-1 strains is highly dependent on the number of CCR5 molecules on the surface of CD4-positive T cells. The molecular mechanisms responsible for this phenomenon remained so far unclear. As CCR5 co-receptors are coupled to G alpha i and G alpha q proteins, we tested the hypothesis that the activation triggered through these proteins secondary to the interaction between the viral envelope and CCR5 could account for the effect of the level of CCR5 expression on HIV-1 production.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0269-9370
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1369-77
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16791011-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16791011-GTP-Binding Protein alpha Subunits, Gi-Go,
pubmed-meshheading:16791011-HIV Infections,
pubmed-meshheading:16791011-HIV-1,
pubmed-meshheading:16791011-Humans,
pubmed-meshheading:16791011-Pertussis Toxin,
pubmed-meshheading:16791011-RNA, Small Interfering,
pubmed-meshheading:16791011-Receptors, CCR5,
pubmed-meshheading:16791011-Signal Transduction,
pubmed-meshheading:16791011-Transduction, Genetic,
pubmed-meshheading:16791011-Tumor Cells, Cultured,
pubmed-meshheading:16791011-Virulence,
pubmed-meshheading:16791011-Virus Replication
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pubmed:year |
2006
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|
pubmed:articleTitle |
The efficiency of R5 HIV-1 infection is determined by CD4 T-cell surface CCR5 density through G alpha i-protein signalling.
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pubmed:affiliation |
Institut de Génétique Humaine, CNRS UPR1142, Montpellier, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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